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We recorded double\u2010pass retinal images with a custom set\u2010up based on a high\u2010sensitivity digital camera. The FSI<jats:sub>3<\/jats:sub> was then computed using spatial frequencies below three cycles per degree. A preliminary validation of the FSI<jats:sub>3<\/jats:sub> was performed on an artificial eye and two eyes of volunteers with and without commercial diffusers, and under defocus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FSI<jats:sub>3<\/jats:sub> was hardly affected by defocus values up to 2.50\u00a0D. The mean (and standard deviation) FSI<jats:sub>3<\/jats:sub> values were as follows: for the CG, 1.19 (0.21); and for LOCSIII grades nuclear opacity 1, 2 and 3, 1.30 (0.12), 1.62 (0.21) and 1.85 (0.21), respectively. Eyes with cataracts showed FSI<jats:sub>3<\/jats:sub> values significantly different than healthy eyes (p\u00a0=\u00a00.001). A good correlation (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.861, p\u00a0&lt;\u00a00.001) was found between the FSI<jats:sub>3<\/jats:sub> and objective scatter index provided by a commercial instrument.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Since aberrations have little impact on the FSI<jats:sub>3<\/jats:sub>, the light scatter assessment becomes less dependent on the patient's refractive error compensation and the presence of higher\u2010order aberrations. The FSI<jats:sub>3<\/jats:sub> can further the clinical and scientific understanding of forward intraocular scattering.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14122","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T10:40:00Z","timestamp":1556880000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quantification of forward scattering based on the analysis of double\u2010pass images in the frequency domain"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-7164","authenticated-orcid":false,"given":"Joan A.","family":"Mart\u00ednez\u2010Roda","sequence":"first","affiliation":[{"name":"Centre for Sensors, Instruments and Systems Development (CD6) Universitat Polit\u00e8cnica de Catalunya (UPC) Terrassa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos 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