{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:03:19Z","timestamp":1792342999349,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To summarize epidemiological evidences on the association between glaucoma and the risk of retinal vein occlusion (<jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>). Relevant studies were identified by searching in PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and Cochrane until February 2018. Fifteen eligible observational studies were aggregated in this analysis. All results were analysed and pooled using random effects models with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>). In all studies, the odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of glaucoma as a risk factor for <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> was 4.01 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.28\u20134.91). In <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> subtype\u2010differentiated subgroup analyses (six studies), the pooled <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> showed that glaucoma was associated with central retinal vein occlusion (<jats:styled-content style=\"fixed-case\">CRVO<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 6.21; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 4.64\u20138.31), branch retinal vein occlusion (<jats:styled-content style=\"fixed-case\">BRVO<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.38; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.77\u20133.19) and hemiretinal vein occlusion (<jats:styled-content style=\"fixed-case\">HRVO<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.60; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.26\u20139.35). In glaucoma\u2010classified subgroup analyses (five studies), primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 5.03; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.97\u20136.37) and chronic open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">COAG<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.36; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.39\u20134.02) were significant risk factors for <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> development. There was a plausible relationship between primary angle closure glaucoma (<jats:styled-content style=\"fixed-case\">PACG<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.85; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.41\u20138.35); to be precise, the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was 5.3 in <jats:styled-content style=\"fixed-case\">PACG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRVO<\/jats:styled-content> risk (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.04\u201326.95; p\u00a0=\u00a00.045), while the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was 0.65 in <jats:styled-content style=\"fixed-case\">PACG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BRVO<\/jats:styled-content> risk (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.07\u20136.27; p\u00a0=\u00a00.707). To sum up, this meta\u2010analysis shows that glaucoma is associated with the risk of <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>. Glaucoma should be kept in mind when investigating patients with <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content> in the clinic.<\/jats:p>","DOI":"10.1111\/aos.14141","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:35:31Z","timestamp":1558712131000},"page":"652-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Association of glaucoma with risk of retinal vein occlusion: A meta\u2010analysis"],"prefix":"10.1111","volume":"97","author":[{"given":"Xue","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Soochow University Suzhou 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