{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:49:35Z","timestamp":1790196575850,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To investigate the scleral and conjunctival features in patients with rhegmatogenous retinal detachment (RRD<\/jats:styled-content>) undergoing scleral buckling (SB), using anterior segment optical coherence tomography (AS<\/jats:styled-content>\u2010OCT<\/jats:styled-content>) and in vivo<\/jats:italic> confocal microscopy (IVCM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty RRD<\/jats:styled-content> eyes were consecutively enrolled. AS<\/jats:styled-content>\u2010OCT<\/jats:styled-content> was performed at RRD<\/jats:styled-content> diagnosis (RRD<\/jats:styled-content>\u2010D) and day 1, week 1, month 1 and month 6 after SB<\/jats:styled-content> to evaluate the sclera, in the affected and unaffected quadrants (AQ<\/jats:styled-content>, UQ<\/jats:styled-content>). IVCM<\/jats:styled-content> was performed at RRD<\/jats:styled-content>\u2010D, and at month 1 and month 6, to evaluate the conjunctiva in AQ<\/jats:styled-content> and UQ<\/jats:styled-content>. The main outcomes were as follows: mean intra\u2010scleral hypo\u2010reflective spaces area (MIHSA) at AS<\/jats:styled-content>\u2010OCT<\/jats:styled-content>; mean density and area of microcysts (MMD<\/jats:styled-content>, MMA<\/jats:styled-content>) at IVCM<\/jats:styled-content>; and intra\u2010ocular pressure (IOP<\/jats:styled-content>). The relations between MIHSA<\/jats:styled-content>, MMA<\/jats:styled-content>, MMD<\/jats:styled-content> and IOP<\/jats:styled-content> were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Rhegmatogenous retinal detachment\u2010 diagnosis (RRD<\/jats:styled-content>\u2010D) overall\u2010mean intra\u2010scleral hypo\u2010reflective spaces (MISHA<\/jats:styled-content>), \u2010MMD<\/jats:styled-content> and \u2010MMA<\/jats:styled-content> were significantly higher in affected eye (AE<\/jats:styled-content>) compared with UE<\/jats:styled-content> (p\u00a0<\u00a00.05) and in AQ<\/jats:styled-content> compared with UQ<\/jats:styled-content> (p\u00a0<\u00a00.05). After SB<\/jats:styled-content>, overall\u2010, AQ<\/jats:styled-content>\u2010 and UQ<\/jats:styled-content>\u2010MISHA<\/jats:styled-content> further increased (p\u00a0<\u00a00.05), whereas overall\u2010MMD<\/jats:styled-content> and \u2010MMA<\/jats:styled-content> did not change. At all follow\u2010up, AQ<\/jats:styled-content> and UQ<\/jats:styled-content> parameters did not show significant differences between them. RRD<\/jats:styled-content>\u2010D IOP<\/jats:styled-content> was 14.3\u00a0\u00b1\u00a02.8 and 15.5\u00a0\u00b1\u00a02.7\u00a0mmHg in the AE<\/jats:styled-content> and UE<\/jats:styled-content>, respectively (p\u00a0<\u00a00.05). After SB<\/jats:styled-content>, week\u20101, month\u20101 and \u20106 IOP<\/jats:styled-content> was significantly lower than RRD<\/jats:styled-content>\u2010D (p\u00a0<\u00a00.05). Rhegmatogenous retinal detachment\u2010 diagnosis (RRD<\/jats:styled-content>\u2010D), 1\u2010 and 6\u2010month overall and AQ<\/jats:styled-content>\u2010MISHA<\/jats:styled-content> and AQ<\/jats:styled-content>\u2010MMD<\/jats:styled-content> negatively correlated with IOP<\/jats:styled-content> (p\u00a0<\u00a00.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Rhegmatogenous retinal detachment (RRD<\/jats:styled-content>) and SB<\/jats:styled-content> induced scleral and conjunctival changes that suggested an activation of fluid outflow through the entire unconventional aqueous humour pathway; these modifications may in part account for the relative hypotony after RRD<\/jats:styled-content> and SB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14148","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:41:54Z","timestamp":1558712514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Scleral and conjunctival features in patients with rhegmatogenous retinal detachment undergoing scleral buckling: an anterior segment optical coherence tomography and in vivo<\/i> confocal microscopy study"],"prefix":"10.1111","volume":"97","author":[{"given":"Paolo","family":"Carpineto","sequence":"first","affiliation":[{"name":"Ophthalmology Clinic Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-6305","authenticated-orcid":false,"given":"Luca","family":"Agnifili","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Senatore","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aharrh\u2010Gnama","family":"Agbeanda","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lappa","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-5031","authenticated-orcid":false,"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Martino","sequence":"additional","affiliation":[{"name":"School of Hygiene Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione G.B. 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