{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:06:52Z","timestamp":1781032012987,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The outer stent lumen can be located either deeper (in or under Tenon's layer) or more superficially in the conjunctival stroma after the transscleral <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content> Glaucoma Gel Microstent (<jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GGM<\/jats:styled-content>; Allergan Plc., <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>) implantation. The present study aimed to investigate the effect of the postoperative conjunctival implant position on surgical success and intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) after <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GGM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective data from 66 consecutive open\u2010angle glaucoma eyes of 54 patients were collected preoperatively and 1 and 2\u00a0weeks, and 1, 6 and 12\u00a0months postoperatively. The layer of implantation was determined in the first month postoperatively as <jats:italic>intra\u2010 and subtenon<\/jats:italic> or <jats:italic>intraconjunctival<\/jats:italic> depending on the location of the outer lumen of the stent in <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> (Visante <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>; Zeiss, Germany). Primary outcome measures were differences in relative <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction at 12\u00a0months between the two groups. Further, complete and qualified surgical success, number of secondary needlings and number of <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010lowering medications and absolute <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction was higher in <jats:italic>intra\u2010 and subtenon<\/jats:italic> group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>37\/66, 56%) at week 1 (\u221254% versus \u221219%, p\u00a0&lt;\u00a00.001), week 2 (\u221239% versus \u221221%, p\u00a0=\u00a00.02), month 1 (\u221242% versus \u221228%, p\u00a0=\u00a00.035) and month 12 (\u221239% versus \u221224%, p\u00a0=\u00a00.024). The mean absolute <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was lower in <jats:italic>intra\u2010 and subtenon group<\/jats:italic> at week 1 (10.8 [95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 8.8\u201314.1] versus 16.6 [95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 14.1\u201319.0] mmHg, p\u00a0&lt;\u00a00.001) and months 12 (13.9 [95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 12.4\u201315.4] versus 16.7 [95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 14.6\u201318.8] mmHg, p\u00a0=\u00a00.041). At month 6, a lower burden for <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010lowering medication was shown for the intra\u2010 and subtenon group (0.2\u00a0\u00b1\u00a00.5 versus 1.0\u00a0\u00b1\u00a01.1, p\u00a0=\u00a00.034). The mean number of secondary needlings, which were done in 47\/66 (71%) of the eyes, was lower in the <jats:italic>intra\u2010 and subtenon<\/jats:italic> group in the first year (1.9\u00a0\u00b1\u00a01.7 versus 1.2\u00a0\u00b1\u00a01.2, p\u00a0=\u00a00.03). Qualified surgical success was higher in the <jats:italic>intra\u2010 and subtenon<\/jats:italic> group (90% versus 61%, p\u00a0=\u00a00.01) after 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study demonstrates a higher efficacy achieved with lower secondary needling rates in deeper implant positions in conjunctiva after <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GGM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14167","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T08:44:51Z","timestamp":1560847491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effect of the outer stent position on efficacy after minimally invasive transscleral glaucoma gel stent implantation"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-7330","authenticated-orcid":false,"given":"Markus","family":"Lenzhofer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Program Experimental Ophthalmology and Glaucoma Research University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Strohmaier","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Program Experimental Ophthalmology and Glaucoma Research University Clinic Salzburg, Paracelsus Medical University Salzburg 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Optometry University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Program Experimental Ophthalmology and Glaucoma Research University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Program Experimental Ophthalmology and Glaucoma Research University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry University Clinic Salzburg, Paracelsus Medical University Salzburg Austria"},{"name":"Research Program Experimental Ophthalmology and Glaucoma Research University Clinic 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