{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:37:43Z","timestamp":1789385863773,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To characterize the phenotype of retinal vessels using central retinal artery equivalent (\n                      <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>\n                      ), central retinal vein equivalent (\n                      <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content>\n                      ), tortuosity and fractal dimension (FD) in primary open\u2010angle glaucoma (\n                      <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>\n                      ) subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective case\u2013control multicentre study included 61\n                      <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>\n                      subjects and 61 controls matched for age, systemic hypertension and body mass index. Fundus images of the right eye were acquired using a non\u2010mydriatic camera. Central retinal artery equivalent (\n                      <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>\n                      ),\n                      <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content>\n                      , arteriole\u2010to\u2010venule ratio,\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      and tortuosity of the vascular network were measured using\n                      <jats:styled-content style=\"fixed-case\">VAMPIRE<\/jats:styled-content>\n                      software (Vessel Assessment and Measurement Platform for Images of the Retina). Primary open\u2010angle glaucoma (\n                      <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>\n                      ) patients underwent 24.2 sita\u2010standard visual field and peri\u2010papillary optical coherence tomography (OCT) examinations. Data were expressed as median and interquartile range (75\u201325th percentiles).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The control group was comparable to the\n                      <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>\n                      group for sex ratio, refraction and intraocular pressure. The mean\n                      <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>\n                      and the mean\n                      <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content>\n                      were significantly lower in the\n                      <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>\n                      group than in the control group [150.5 (137.9; 157.1)\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m versus 161.3 (154.0; 168.4)\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m and 204.8 (190.1; 218.1)\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m versus 233.5 (222.3; 246.9)\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m, respectively; p\u00a0&lt;\u00a00.001] and for fractal parameters as well. No significant difference was found for tortuosity between the two groups. There was a significant correlation between\n                      <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>\n                      and retinal nerve fibre layer (RNFL) thickness (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.27; p\u00a0=\u00a00.03).\n                      <jats:styled-content style=\"fixed-case\">VAMPIRE<\/jats:styled-content>\n                      parameters were not correlated with visual field indices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Primary open\u2010angle glaucoma (\n                      <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>\n                      ) was associated with a narrowing of arterial and venous retinal vessels, a higher arteriole\u2010to\u2010venule ratio and lower values of FD. The relationship between\n                      <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>\n                      and RNFL thickness needs further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14192","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:19:54Z","timestamp":1564445994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Retinal vessel phenotype in patients with primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-4885","authenticated-orcid":false,"given":"Christophe","family":"Chiquet","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital of Grenoble Grenoble France"},{"name":"Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gavard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Grenoble Grenoble France"},{"name":"Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-8818","authenticated-orcid":false,"given":"Louis","family":"Arnould","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Mautuit","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Grenoble Grenoble France"},{"name":"Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J.","family":"Macgillivray","sequence":"additional","affiliation":[{"name":"VAMPIRE Project Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain M.","family":"Bron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Semecas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Grenoble Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuele","family":"Trucco","sequence":"additional","affiliation":[{"name":"VAMPIRE Project Computing, School of Science and Engineering University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aptel","family":"Florent","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Grenoble Grenoble France"},{"name":"Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2142"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.04.016"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d7d8b4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.10.047"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01200-4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90525-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1459"},{"key":"e_1_2_5_9_1","first-page":"1599","article-title":"Parapapillary retinal vessel diameter in normal and glaucoma eyes. 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