{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:53:56Z","timestamp":1787298836143,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To study the prevalence of resolved paracentral acute middle maculopathy (PAMM<\/jats:styled-content>) lesions in fellow eyes of patients with unilateral retinal vein occlusion (RVO<\/jats:styled-content>) and eyes of healthy individuals.<\/jats:p><\/jats:sec>Methods<\/jats:title>This case\u2013control observational study took place in a referral university medical centre. Forty\u2010five (17 males, 28 females, 64.7\u00a0\u00b1\u00a010.8\u00a0years) patients with branch retinal vein occlusion (BRVO<\/jats:styled-content>), 21 (17 males, 4 females, 68.8\u00a0\u00b1\u00a011.2\u00a0years) patients with central retinal vein occlusion (CRVO<\/jats:styled-content>) and 57 healthy individuals (25 males, 32 females, 67.4\u00a0\u00b1\u00a010.5\u00a0years) were included. Presence of resolved PAMM<\/jats:styled-content> lesions was evaluated by reviewing cross\u2010sectional scans of 8\u2010mm optical coherence tomography angiography protocol. Resolved PAMM<\/jats:styled-content> lesion was defined as inner nuclear layer thinning with outer plexiform layer elevation.<\/jats:p><\/jats:sec>Results<\/jats:title>Resolved PAMM<\/jats:styled-content> lesions were found in 32\/45 (71.1%) and 15\/21 (71.4%) of BRVO<\/jats:styled-content> and CRVO<\/jats:styled-content> patients, respectively. In healthy volunteers, resolved PAMM<\/jats:styled-content> lesions were found in 11\/57 (19.3%) individuals with bilateral involvement in 8 individuals (72.7%). RVO<\/jats:styled-content> patients demonstrated the presence of resolved PAMM<\/jats:styled-content> lesions in fellow eye significantly more frequently than healthy individuals (odds ratio (OR<\/jats:styled-content>) 10.6, p\u00a0<\u00a00.001, 95% CI<\/jats:styled-content> 4.5\u201324.6). OR<\/jats:styled-content> for the presence of large resolved PAMM<\/jats:styled-content> lesions in BRVO<\/jats:styled-content> patients and CRVO<\/jats:styled-content> patients versus healthy individual was 12.1 (p\u00a0=\u00a00.02, 95% CI<\/jats:styled-content> 1.5\u2013100.9) and 22.4 (p\u00a0=\u00a00.005, 95% CI<\/jats:styled-content> 2.5\u2013200.6), respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Resolved PAMM<\/jats:styled-content> lesions defined as inner nuclear layer thinning associated with outer plexiform layer elevation are highly prevalent in fellow eyes of patients with unilateral RVO<\/jats:styled-content>. Resolved PAMM<\/jats:styled-content> lesions may have an association with RVO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14196","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T06:19:23Z","timestamp":1564121963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-3982","authenticated-orcid":false,"given":"Dmitrii S.","family":"Maltsev","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Military Medical Academy St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei N.","family":"Kulikov","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Military Medical Academy St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Burnasheva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Military Medical Academy St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-3558","authenticated-orcid":false,"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"Smt. Kanuri Santhamma Retina Vitreous Centre L.V. Prasad Eye Institute Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18907"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.07.031"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.01.018"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.05.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182870c15"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24348"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/724780"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000709"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.10.026"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442806"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001077"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2017.09.024"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12982"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000696"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.09.027"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:32:20Z","timestamp":1693913540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/aos.14196"],"URL":"https:\/\/doi.org\/10.1111\/aos.14196","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]},"assertion":[{"value":"2019-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}