{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:56:19Z","timestamp":1789343779916,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T00:00:00Z","timestamp":1566000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To assess dimensions and associations of the peripapillary border tissue of the choroid (\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C) and peripapillary scleral flange (\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010S).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The histomorphometric investigation included histological sections of enucleated eyes of Caucasian patients. Using light microscopy, the\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      dimensions were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 85 eyes (85 patients) with an age of 62.0\u00a0years (14.1\u00a0years) (mean (\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      )) (range:37\u201387\u00a0years) and mean axial length of 26.7\u00a0mm (3.5\u00a0mm) (range:21.0\u201337.0\u00a0mm). Thicker\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C thickness (mean: 68.8\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m (35.7\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m)) was associated with shorter axial length (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001; standardized regression coefficient beta: \u22120.50), and longer\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C length (mean: 531\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m (802\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m)) was correlated with longer axial length (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001;beta:0.66).\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C cross\u2010sectional area (mean 17\u00a0050\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m\n                      <jats:sup>2<\/jats:sup>\n                      (10\u00a0420\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m\n                      <jats:sup>2<\/jats:sup>\n                      )) was not significantly associated with axial length (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.37). Decreasing with longer axial length (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001;beta:0.64), the angle between\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C and Bruch's membrane was approximately 90\u00b0 in non\u2010highly myopic eyes without overhanging Bruch's membrane (\n                      <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\n                      ), it ranged between 100\u00b0 and 180\u00b0 in eyes with\n                      <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\n                      overhanging into the intrapapillary region, and it was close to 0\u00b0 in eyes with parapapillary gamma zone. Thicker thickness of\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010S (mean:83\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m (21\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m)) was correlated with presence of glaucoma (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.02). Optic nerve pia mater thickness (mean:109\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m (44\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      m)) increased with glaucoma presence (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.046;beta:0.31) but not with axial length (p\n                      <jats:italic>\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.34).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Peripapillary border tissue of the choroid (PBT\u2010C) and\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010S as continuation of the optic nerve pia mater are distinct structures, with\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C remodelling during myopic axial elongation and\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010S being mostly independent of axial elongation.\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C and\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010S may be of importance for the optic nerve head biomechanics and\n                      <jats:styled-content style=\"fixed-case\">PBT<\/jats:styled-content>\n                      \u2010C for separation of the choroidal space from the intrapapillary compartment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14206","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T09:03:58Z","timestamp":1566032638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Peripapillary border tissue of the choroid and peripapillary scleral flange in human eyes"],"prefix":"10.1111","volume":"98","author":[{"given":"Rahul A.","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Holbach","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1969.00990020792015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990030065013"},{"key":"e_1_2_5_4_1","first-page":"243","article-title":"Anatomische Untersuchung \u00fcber die Beziehung zwischen der senilen und myopischen circumpapill\u00e4ren Aderhautatrophie. Unter Beif\u00fcgen eines Falles von hochgradiger Anisometropie","volume":"121","author":"B\u00fccklers M","year":"1929","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200110001-00007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18718"},{"key":"e_1_2_5_7_1","first-page":"391","article-title":"Das Colobom am Sehnerveneintritte und der Conus nach unten","volume":"51","author":"Elschnig A","year":"1900","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_5_8_1","unstructured":"ElschnigA(1901):Der normale Sehnerveneintritt des menschlichen Auges. Denkschrift der kais Akad der Wiss Wien Math.\u2010naturw. Kl 70:219\u2010310."},{"key":"e_1_2_5_9_1","first-page":"OP240","article-title":"Anatomy and physiology of the optic nerve head","volume":"78","author":"Hayreh SS","year":"1974","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(66)90758-6"},{"key":"e_1_2_5_11_1","volume-title":"Histology of the human eye. An atlas and textbook. Chapter 10 Optic nerve","author":"Hogan MJ","year":"1971"},{"key":"e_1_2_5_12_1","first-page":"129","article-title":"\u00dcber die Neuroglia des Sehnerven","volume":"43","author":"Jacoby E","year":"1905","journal-title":"Klin Mbl Augenheilk"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02088.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047237"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12324"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093551"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12372"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136833"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12937"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18529"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19885"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18263"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000574"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001464"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13188"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13537"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.051"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01693917"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02570.x"},{"key":"e_1_2_5_30_1","first-page":"94","volume-title":"The anatomy and histology of the human eyeball in the normal state; its development and senescence","author":"Salzmann M","year":"1912"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15631"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000947"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18986"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.048"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T07:31:23Z","timestamp":1693899083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,17]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/aos.14206"],"URL":"https:\/\/doi.org\/10.1111\/aos.14206","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,17]]},"assertion":[{"value":"2019-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}