{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T04:52:28Z","timestamp":1777783948069,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the changes in peripapillary retinal nerve fiber layer (<jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content>), macular and ganglion cell\u2010inner plexiform layer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>) thicknesses in patients with acute anterior uveitis (<jats:styled-content style=\"fixed-case\">AAU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with unilateral non\u2010infectious <jats:styled-content style=\"fixed-case\">AAU<\/jats:styled-content> and normal control were enrolled retrospectively. Optical coherence tomography scans were performed during the initial active phase and inactive phase of <jats:styled-content style=\"fixed-case\">AAU<\/jats:styled-content>. Patients were followed for at least 3\u00a0months after resolution of inflammatory activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven <jats:styled-content style=\"fixed-case\">AAU<\/jats:styled-content> patients and 40 controls were included. The average <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> and central macular thickness (CMT) showed significant differences between patients and control groups during active phase (p\u00a0&lt;\u00a00.001 and p\u00a0=\u00a00.022, respectively). The average <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> thicknesses of affected eyes and fellow eyes during the active phase were 109.4\u00a0\u00b1\u00a012.5\u00a0<jats:italic>\u03bc<\/jats:italic>m and 96.5\u00a0\u00b1\u00a08.0\u00a0<jats:italic>\u03bc<\/jats:italic>m, respectively (p\u00a0&lt;\u00a00.001). During the inactive phase, the average thicknesses were 99.3\u00a0\u00b1\u00a08.9\u00a0<jats:italic>\u03bc<\/jats:italic>m and 97.0\u00a0\u00b1\u00a07.5, respectively; they were not significantly different (p\u00a0=\u00a00.236). The CMTs of affected and fellow eyes during the active phase were 261.6\u00a0\u00b1\u00a024.7\u00a0<jats:italic>\u03bc<\/jats:italic>m and 251.5\u00a0\u00b1\u00a017.3\u00a0<jats:italic>\u03bc<\/jats:italic>m, respectively; the difference was significant (p\u00a0=\u00a00.047). The average <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content> thicknesses of affected and fellow eyes were not significantly different (p\u00a0=\u00a00.061).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> and central macula thickened during the active phase of <jats:styled-content style=\"fixed-case\">AAU<\/jats:styled-content> and decreased to a similar degree with fellow eyes during the inactive phase. Additionally, <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> thickness showed a sensitive response to the degree of inflammation in <jats:styled-content style=\"fixed-case\">AAU<\/jats:styled-content>. This suggests that <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> thickness may be useful in assessing disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14221","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T14:40:24Z","timestamp":1569249624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characteristics of retinal layer thickness in acute anterior uveitis: an optical coherence tomography study"],"prefix":"10.1111","volume":"98","author":[{"given":"Min\u2010Woo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chungnam National University College of Medicine Daejeon Korea"},{"name":"Department of Ophthalmology Konyang University College of Medicine Daejeon 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