{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:44:19Z","timestamp":1790091859141,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>8\/<jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>8 cytokine and its receptor <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>1 in tear film and ocular surface of patients with ocular mucous membrane pemphigoid (oMMP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with <jats:styled-content style=\"fixed-case\">oMMP<\/jats:styled-content> in the quiescent phase, 20 patients with primary Sjogren syndrome (<jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>) and 13 age\u2010 and sex\u2010matched healthy controls (HCs) were included in this study. All patients undergone complete eye examination including lacrimal function tests and ocular surface staining assessed by ocular staining score. Ocular mucous membrane pemphigoid (oMMP) staging according to Mondino classification and dry eye severity grade according to Dry Eye Workshop 2007 classification were recorded. Tear samples and conjunctival epithelium were collected. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 tear concentration was measured by enzyme\u2010linked immunosorbent assay, and conjunctival <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>8 was analysed by Western blot; conjunctival expression of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>1 was evaluated by immunohistochemistry. Il\u20108 and <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>1 expression in <jats:styled-content style=\"fixed-case\">oMMP<\/jats:styled-content> patients were compared with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>and <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content> patients and correlated with ocular clinical findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tear levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 were significantly increased in patients with\u00a0<jats:styled-content style=\"fixed-case\">oMMP<\/jats:styled-content> (260.1\u00a0\u00b1\u00a070\u00a0pg\/ml) when compared to both HCs (98.5\u00a0\u00b1\u00a071.35\u00a0pg\/ml; p\u00a0=\u00a00.001) and patients with <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content> (96.3\u00a0\u00b1\u00a087.5\u00a0pg\/ml; p\u00a0=\u00a00.001). Conjunctival expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>1 was significantly increased in <jats:styled-content style=\"fixed-case\">oMMP<\/jats:styled-content> patients when compared to both healthy subjects and <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The significant increase of tear and conjunctival <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>1 levels in patients with <jats:styled-content style=\"fixed-case\">oMMP<\/jats:styled-content> when compared to healthy subjects and patients with Sjogren syndrome suggests that changes of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>8 pathway are specific of <jats:styled-content 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