{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:34:52Z","timestamp":1769502892263,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare postoperative macular thickness measurements of inner and outer retinal layers in eyes of patients with chiasmal compression with or without visual field (<jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>) recovery and healthy controls using optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Macular spectral\u2010domain <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> has been used for the auto\u2010segmentation of images obtained from 100 eyes affected with chiasmal compression compared with 100 healthy controls enrolled in this study. We have divided eyes with chiasmal compression into two groups: group 1 characterized by <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> recovery after tumour excision and group 2 showing partial or no recovery of <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>. The thickness of the macular retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>), ganglion cell layer (<jats:styled-content style=\"fixed-case\">GCL<\/jats:styled-content>), inner plexiform layer (<jats:styled-content style=\"fixed-case\">IPL<\/jats:styled-content>), inner nuclear layer (<jats:styled-content style=\"fixed-case\">INL<\/jats:styled-content>), outer plexiform layer (<jats:styled-content style=\"fixed-case\">OPL<\/jats:styled-content>), outer nuclear layer (<jats:styled-content style=\"fixed-case\">ONL<\/jats:styled-content>), photoreceptor layer (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>), inner retinal layer (<jats:styled-content style=\"fixed-case\">IRL<\/jats:styled-content>) and outer retinal layer (<jats:styled-content style=\"fixed-case\">ORL<\/jats:styled-content>) was segmented. The correlation between macular <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">mRNFL<\/jats:styled-content>) and functional parameters has been analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups 1 and 2 showed significant thinning of <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IPL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IRL<\/jats:styled-content> in all quadrants. However, no significant changes have been detected in <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ORL<\/jats:styled-content> of patients in either group compared with healthy controls. A significant thickening was detected in <jats:styled-content style=\"fixed-case\">INL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ONL<\/jats:styled-content> of group 2 compared with healthy controls and group 1. Postoperative <jats:styled-content style=\"fixed-case\">mRNFL<\/jats:styled-content> thickness is significantly correlated with <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> defects and visual acuity except temporal quadrant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Eyes with chiasmal compression showed thinning of the inner retinal layers with thickening of the <jats:styled-content style=\"fixed-case\">INL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ONL<\/jats:styled-content> in patients with partial to no recovery of <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>. The changes in retinal microstructures are well\u2010correlated with functional recovery. Further studies are needed to reveal the clinical implications of these findings in patients with chiasmal compression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14271","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T05:29:05Z","timestamp":1570771745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Optical coherence tomography analysis of inner and outer retinal layers in eyes with chiasmal compression caused by suprasellar tumours"],"prefix":"10.1111","volume":"98","author":[{"given":"Ga\u2010In","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 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