{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T04:24:19Z","timestamp":1774153459599,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To investigate the short\u2010time effect of intravitreal injections (IVI<\/jats:styled-content>) of the vascular endothelial growth factor inhibitors ranibizumab and aflibercept on retinal arterial and venous oxygen saturation (SO<\/jats:styled-content>2a and SO<\/jats:styled-content>2v), arteriovenous oxygen saturation difference (AVD<\/jats:styled-content>) and vessel diameter (VD<\/jats:styled-content>a and VD<\/jats:styled-content>v) in patients with diabetic macular oedema (DME<\/jats:styled-content>) and patients with choroidal neovascularization (CNV<\/jats:styled-content>) due to age\u2010related macular degeneration.<\/jats:p><\/jats:sec>Methods<\/jats:title>Uncontrolled prospective observational study in 100 eyes. Retinal vessel oxygen saturation and diameters were assessed using a retinal oximeter before and minutes after IVI<\/jats:styled-content> of ranibizumab or aflibercept.<\/jats:p><\/jats:sec>Results<\/jats:title>40 eyes with CNV<\/jats:styled-content> and 34 eyes with DME<\/jats:styled-content> were included in the analysis. At baseline, SO<\/jats:styled-content>2a and SO<\/jats:styled-content>2v were significantly higher in DME<\/jats:styled-content> (p\u00a0=\u00a00.043 and p\u00a0=\u00a00.009, respectively). After IVI<\/jats:styled-content>, SO<\/jats:styled-content>2a significantly decreased in CNV<\/jats:styled-content> and DME<\/jats:styled-content> eyes by 2.6% (p\u00a0=\u00a00.016) and 4.6% (p\u00a0=\u00a00.002) and SO<\/jats:styled-content>2v decreased by 14.0% (p\u00a0=\u00a00.004) and 12.4% (p\u00a0=\u00a00.017), respectively. However, a significant increase in AVD<\/jats:styled-content> was only found in CNV<\/jats:styled-content> (15.7%, p\u00a0=\u00a00.001). VD<\/jats:styled-content>a decreased significantly only in DME<\/jats:styled-content> by 5.7% (p\u00a0=\u00a00.010). No medication\u2010specific disease effect was found and vice versa.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The observed changes can be interpreted as signs of increased metabolic demand during the physiological stress after an IVI<\/jats:styled-content>. The abnormal arterial constriction and the abolished increase in AVD<\/jats:styled-content> seen only in eyes with DME<\/jats:styled-content> indicate an impairment of vascular autoregulation and oxygen distribution and a reduced neuroretinal metabolism in the diabetic retina with a significant impact on inner retinal oxygen consumption shortly after IVI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14276","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T05:58:18Z","timestamp":1572069498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short\u2010time effect of intravitreal injections on retinal vascular oxygenation and vessel diameter in patients with diabetic macular oedema or neovascular age\u2010related macular degeneration"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-5418","authenticated-orcid":false,"given":"Christoph","family":"Mitsch","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-0229","authenticated-orcid":false,"given":"Berthold","family":"Pemp","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pollreisz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Gleiss","sequence":"additional","affiliation":[{"name":"Center for Medical 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