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We studied plasma levels of inflammatory chemokines in patients with polypoidal choroidal vasculopathy (<jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>) and compared with healthy age\u2010matched control individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a clinic\u2010based prospective case\u2013control study of participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) with either <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) or age\u2010matched healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a034). We sampled fresh venous blood and isolated plasma for analysis. We used U\u2010<jats:styled-content style=\"fixed-case\">PLEX<\/jats:styled-content> Human Assays to quantify concentrations of the inflammatory chemokines <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5, eotaxin\/<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>11, <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010\/<jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>10 and fractalkine\/<jats:styled-content style=\"fixed-case\">CX<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma levels of fractalkine was significantly higher in patients with <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> when compared to healthy controls (mean\u00a0\u00b1\u00a0SD: 7291\u00a0\u00b1\u00a02461\u00a0pg\/ml versus 5879\u00a0\u00b1\u00a02001\u00a0pg\/ml; p\u00a0=\u00a00.021). Plasma levels of <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 (p\u00a0=\u00a00.846), <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content> (p\u00a0=\u00a00.288), eotaxin (p\u00a0=\u00a00.496) and <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u201010 (p\u00a0=\u00a00.352) did not differ significantly between the groups. To evaluate possible biomarker quality of fractalkine, we used a <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis and found a positive but weak discriminatory ability (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> have a higher plasma level of fractalkine. Although the differences do not possess strong biomarker qualities, they inform on disease processes of a poorly understood disease and suggest that the fractalkine\u2010<jats:styled-content style=\"fixed-case\">CX<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1 axis may be involved. As this study did not investigate local chemokine concentrations, we are unable to confirm or disprove any local chorioretinal interaction, and our findings should be interpreted with such caution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14295","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T05:44:45Z","timestamp":1572846285000},"page":"384-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Plasma levels of inflammatory chemokines in patients with polypoidal choroidal vasculopathy"],"prefix":"10.1111","volume":"98","author":[{"given":"Jakob \u00d8rskov","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Clinical Eye Research Division Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Department of Ophthalmology Rigshospitalet-Glostrup Glostrup 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