{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:37:00Z","timestamp":1790181420199,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T00:00:00Z","timestamp":1573948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate the clinical and economic burden of dry eye disease (\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      ) among affected patients in Germany.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult patients (\u226518\u00a0years) with \u22651 confirmed diagnosis of\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      during the study period (2008\u20132015) were identified from the medical claims of ~3.6\u00a0million insured patients from Betriebskrankenkassen, a German statutory health insurance database. Prevalence (per 1000 patients) and incidence (per 1000 person\u2010years at risk) were estimated, and demographic and clinical characteristics, treatment history (excluding over\u2010the\u2010counter tear supplements), healthcare resource use (\n                      <jats:styled-content style=\"fixed-case\">HCRU<\/jats:styled-content>\n                      ) and costs were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this population, the prevalence of\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      increased from 20.24 in 2008 to 23.13 per 1000 patients in 2014. Overall incidence was 6.24 per 1000 person\u2010years at risk (2008\u20132015). Prevalence and incidence increased with age and were higher in women. Mean age at index was 63.4\u00a0years (incident cohort,\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      35\u00a0026). The most common ocular comorbidity was cataract (48.5%), and ~36% of patients were dispensed a reimbursed\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      \u2010specific medication during the postindex period \u2013 most commonly, corticosteroids alone (13.2%) or in combination with anti\u2010infectives (21.8%).\n                      <jats:styled-content style=\"fixed-case\">HCRU<\/jats:styled-content>\n                      was high in patients with\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      , mostly due to comorbidities.\n                      <jats:styled-content style=\"fixed-case\">HCRU<\/jats:styled-content>\n                      and associated costs were highest in patients \u226560\u00a0years. Total costs during the postindex period were higher in the\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      cohort than among matched controls (\u20ac117\u00a0million versus \u20ac107\u00a0million; p\u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This retrospective database analysis provides a better understanding of the epidemiology, clinical characteristics, real\u2010world treatment patterns,\n                      <jats:styled-content style=\"fixed-case\">HCRU<\/jats:styled-content>\n                      and costs associated with\n                      <jats:styled-content style=\"fixed-case\">DED<\/jats:styled-content>\n                      in patients living in Germany.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14300","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T01:16:55Z","timestamp":1574039815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Burden of dry eye disease in Germany: a retrospective observational study using German claims data"],"prefix":"10.1111","volume":"98","author":[{"given":"Csaba","family":"Siffel","sequence":"first","affiliation":[{"name":"Takeda Lexington MA USA"},{"name":"College of Allied Health Sciences Augusta University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Hennies","sequence":"additional","affiliation":[{"name":"IQVIA Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Joseph","sequence":"additional","affiliation":[{"name":"Takeda Lexington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Lascano","sequence":"additional","affiliation":[{"name":"IQVIA London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Horvat","sequence":"additional","affiliation":[{"name":"IQVIA London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Scheider","sequence":"additional","affiliation":[{"name":"Team Gesundheit Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ganzera","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis Dr. Ganzera\/Luedke Kulmbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.03.001"},{"key":"e_1_2_6_3_1","unstructured":"Berufsverband der Augen\u00e4rzte Deutschlands e.V.&Deutsche Ophthalmologische Gesellschaft(2019):Leitlinie nr. 11 trockenes auge. 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