{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:33:01Z","timestamp":1788316381653,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009471","name":"EkstraStiftelsen Helse og Rehabilitering","doi-asserted-by":"publisher","award":["2015\/FO8068"],"award-info":[{"award-number":["2015\/FO8068"]}],"id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the corneal endothelial cell density (<jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content>) before and after cataract surgery in patients with and without pseudoexfoliation syndrome (<jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, we compared the <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> in 62 <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> patients with 62 patients without <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> (controls). The mean age was 78.3\u00a0\u00b1\u00a06.2\u00a0years and 77.2\u00a0\u00b1\u00a05.9\u00a0years, respectively. Patients were examined before and at 6\u00a0months, 1\u00a0year and 2\u00a0years after cataract surgery. The corneal endothelium was examined with confocal microscopy, and the <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> was counted both automatically and semi\u2010manually. Nine patients in the <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> group (15%) and 11 patients in the control group (18%) were lost to follow\u2010up in the 2\u2010year period. Within the <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> and the control groups, we also compared the <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> between patients with and without glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before surgery, the <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> (semi\u2010manual counting) was 2258\u00a0\u00b1\u00a0342\u00a0cells\/mm<jats:sup>2<\/jats:sup> in the <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> group and 2322\u00a0\u00b1\u00a0321\u00a0cells\/mm<jats:sup>2<\/jats:sup> in the control group (p\u00a0=\u00a00.29). There were no significant differences in postoperative <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> between these groups at any visit. After 2\u00a0years, the <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> had changed by \u2212679\u00a0\u00b1\u00a0337 cells\/mm<jats:sup>2<\/jats:sup> and \u2212704\u00a0\u00b1\u00a0484 cells\/mm<jats:sup>2<\/jats:sup>, respectively (p\u00a0=\u00a00.78). The preoperative <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> was lower in eyes with glaucoma compared to eyes without glaucoma, both within the <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> group (p\u00a0=\u00a00.05) and the control group (p\u00a0=\u00a00.03). After surgery, there were no differences between eyes with or without glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> was not significantly different in <jats:styled-content style=\"fixed-case\">PEX<\/jats:styled-content> eyes compared with control eyes, neither before nor after cataract surgery. However, there seemed to be a lower <jats:styled-content style=\"fixed-case\">ECD<\/jats:styled-content> in eyes with glaucoma before surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14314","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T05:20:24Z","timestamp":1574832024000},"page":"337-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Corneal endothelial cell loss following cataract surgery in patients with pseudoexfoliation syndrome: a 2\u2010year prospective comparative study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-9811","authenticated-orcid":false,"given":"Olav","family":"Kristianslund","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Oslo University Hospital Oslo 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