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Reported data included different methods of treatment and both results of diagnostic examinations [fluorescein angiography and\/or optical coherent tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>)] and best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) before and after therapy. The duration of observation had a mean of 11\u00a0months but was extended in a minority of cases up to 7\u00a0years. The aim of this study is to evaluate the efficacy of the different therapeutic options of <jats:styled-content style=\"fixed-case\">CSCR<\/jats:styled-content> in terms of both visual (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) and anatomic (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand seven hundred nineteen patients (1861 eyes) diagnosed with <jats:styled-content style=\"fixed-case\">CSCR<\/jats:styled-content> were included. Treatments performed were nonsteroidal anti\u2010inflammatory eye drops, laser photocoagulation, micropulse diode laser photocoagulation, photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>; Standard <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, Reduced\u2010dose <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, Reduced\u2010fluence <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>), intravitreal (<jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content>) antivascular endothelial growth factor injection (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>), observation and other treatments. The list of the <jats:styled-content style=\"fixed-case\">OTHERS<\/jats:styled-content> included both combinations of the main proposed treatments or a variety of other treatments such as eplerenone, spironolactone, acetazolamide, beta\u2010blockers, anti\u2010anxiety drugs, aspirin, folic acid, methotrexate, statins, vitis vinifera extract medication and pars plana vitrectomy. The majority of the patients were men with a prevalence of 77%. The odds ratio (OR) showed a partial or complete resolution of fluid on <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> with any treatment as compared with observation. In univariate analysis, the anatomical result (improvement in subretinal fluid using <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> at 1\u00a0month) was favoured by age &lt;60\u00a0years (p\u00a0&lt;\u00a00.005), no previous observation (p\u00a0&lt;\u00a00.0002), duration less than 3\u00a0months (p\u00a0&lt;\u00a00.0001), absence of <jats:styled-content style=\"fixed-case\">CSCR<\/jats:styled-content> in the fellow eye (p\u00a0=\u00a00.04), leakage outside of the arcade (p\u00a0=\u00a00.05) and fluid height &gt;500\u00a0<jats:italic>\u03bc<\/jats:italic>m (p\u00a0=\u00a00.03). The OR for obtaining partial or complete resolution showed that anti\u2010<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and eyedrops were not statistically significant; whereas <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> (8.5), thermal laser (11.3) and micropulse laser (8.9) lead to better anatomical results with less variability. In univariate analysis, the functional result at 1\u00a0month was favoured by first episode (p\u00a0=\u00a00.04), height of subretinal fluid &gt;500\u00a0<jats:italic>\u03bc<\/jats:italic>m (p\u00a0&lt;\u00a00.0001) and short duration of observation (p\u00a0=\u00a00.02). Finally, there was no statistically significant difference among the treatments at 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spontaneous resolution has been described in a high percentage of patients. Laser (micropulse and thermal) and <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> seem to lead to significant early anatomical improvement; however, there is little change beyond the first month of treatment. The real visual benefit needs further clarification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14319","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T09:08:20Z","timestamp":1575623300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An international collaborative evaluation of central serous chorioretinopathy: different therapeutic approaches and review of literature. 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Anna Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-706X","authenticated-orcid":false,"given":"Davide","family":"Allegrini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Gavazzeni \u2010 Castelli Hospital Humanitas University Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-9218","authenticated-orcid":false,"given":"Zofia","family":"Michalewska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Klinika Okulistyczna Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Adelman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Yale University New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6579","authenticated-orcid":false,"given":"Stefanos","family":"Bonovas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Pieve Emanuele, Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bopp","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Science Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EVRS study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1212-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S17182"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200312000-00002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.12.1453"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00462-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.04.014"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.08.026"},{"key":"e_1_2_5_9_1","first-page":"144","article-title":"Central serous retinopathy","volume":"74","author":"Dellaporta A","year":"1976","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.72.11.829"},{"key":"e_1_2_5_11_1","first-page":"456","article-title":"Photocoagulation treatment of idiopathic central serous choroidopathy","volume":"83","author":"Gass JD","year":"1977","journal-title":"Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.11.815"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.55"},{"key":"e_1_2_5_14_1","first-page":"2322","article-title":"Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7\u00a0weeks after treatment","volume":"40","author":"Husain D","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199911000-00005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181be0a83"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903188425"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12125"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.07.005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.02.032"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1974.03900060257001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.11.079"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.090282"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.63.10.674"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360014"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181d8e7fe"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2013.812549"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.023"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.83.6.853"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.07.004"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1001\/archopht.117.10.1329","article-title":"Photodynamic therapy of subfoveal choroidal neovascularization in age\u2010related macular degeneration with verteporfin: one\u2010year results of 2 randomized clinical trials\u2013TAP report. 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