{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:44:09Z","timestamp":1758401049048,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate and correlate levels of various proteins involved in coagulation, inflammation and angiogenesis processes in the vitreous of patients with different vitreoretinal pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vitreous samples were collected from patients scheduled for pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD), vitreous haemorrhage or tractional retinal detachment associated with proliferative diabetic retinopathy (PDR). Macular hole and epiretinal membrane served as controls. Levels of vascular endothelial growth factor, thrombin\u2013antithrombin <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> complex, interleukin\u20108, tissue factor, thrombomodulin, P\u2010selectin, D\u2010dimer and tissue factor pathway inhibitor were compared among the vitreoretinal pathology groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, patients with PDR had significantly higher levels of thrombin\u2013antithrombin <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> complex (p\u00a0&lt;\u00a00.001), vascular endothelial growth factor (p\u00a0&lt;\u00a00.001), D\u2010dimer (p\u00a0=\u00a00.038) and interleukin\u20108 (p\u00a0=\u00a00.04), and patients with RRD group had significantly higher levels only of thrombin\u2013antithrombin <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> complex (p\u00a0&lt;\u00a00.001). There was a significant linear correlation between levels of P\u2010selectin and D\u2010dimer (p\u00a0=\u00a00.003), P\u2010selectin and interleukin\u20108 (p\u00a0&lt;\u00a00.001), and D\u2010dimer and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 (p\u00a0=\u00a00.007). These correlations were particularly strong in the PDR group compared to the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with PDR manifest high coagulative and angiogenic activity in the vitreous. These pathways are highly correlated with the inflammatory cascade.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14331","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T06:56:37Z","timestamp":1576220197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inflammation, angiogenesis and coagulation interplay in a variety of retinal diseases"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9550-6893","authenticated-orcid":false,"given":"Idit","family":"Dan\u2010Brezis","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rabin Medical Center \u2013 Beilinson Hospital Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-5253","authenticated-orcid":false,"given":"Alon","family":"Zahavi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 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