{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:25:36Z","timestamp":1763058336304,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Patients with pseudoxanthoma elasticum (PXE) develop calcification of Bruch's membrane (BM) and choroidal thinning, as well as calcification of intracranial arteries, leading to arterial stiffness. We investigated whether arterial stiffness is associated with choroidal thinning in PXE patients, besides the presumed effect of BM calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study with 75 PXE patients and 40 controls. Macular choroidal thickness was measured using optical coherence tomography scans. Functional magnetic resonance imaging was used to calculate the pulsatility index (PI) of the carotid siphon as a measure of arterial stiffness. Associations between PI and choroidal thickness were investigated using linear mixed effects models adjusted for age and ocular axial length. Furthermore, we investigated choroidal thickness in relation to the presence of retinal pigment epithelium (RPE) atrophy, its topographical distribution and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 58\u00a0years (IQR 53\u201366) in PXE patients and 62\u00a0years (IQR 56\u201367) in controls (p\u00a0=\u00a00.08). Pseudoxanthoma elasticum (PXE) patients had a thinner choroid than controls (138\u00a0\u03bcm versus 248\u00a0\u03bcm, p\u00a0&lt;\u00a00.01). No association was observed between PI and choroidal thickness in PXE patients (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22121.6, 95% CI \u221259.4 to 54.5) nor in controls (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u221247.6, 95% CI \u2212129.7 to 31.9). In PXE patients, RPE atrophy was associated with a thinner choroid (p\u00a0&lt;\u00a00.01). Also, the nasal choroid was thinner than the temporal choroid, and choroidal thickness already decreased with age in PXE eyes without RPE atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no independent association between measures of arterial stiffness and choroidal thinning in PXE patients and controls. Probably, changes in BM lead to choroidal thinning in PXE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14346","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T05:13:55Z","timestamp":1578978835000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is arterial stiffness in the carotid artery associated with choroidal thinning in patients with pseudoxanthoma elasticum or controls?"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-797X","authenticated-orcid":false,"given":"Sara","family":"Risseeuw","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Bartstra","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Ossewaarde \u2013 van Norel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart J.","family":"Geurts","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherina H.Z.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia M.","family":"Imhof","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University 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