{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:25Z","timestamp":1787013865358,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["T.N. 26293372"],"award-info":[{"award-number":["T.N. 26293372"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["T.N. 26670751"],"award-info":[{"award-number":["T.N. 26670751"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma visual field defect progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, longitudinal study comprised 28 eyes of 16 patients with open\u2010angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue\u2010area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT\u2010change). Follow\u2010up data were collected for at least 2\u00a0years, including at least 5 reliable visual field tests. The average total deviation (TD) was calculated in each sector of the Garway\u2010Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT\u2010change, respectively. MT and MT\u2010change in three sectors per eye were included as explanatory variables in a multivariable linear mixed\u2010effects model, with TD slope set as the response variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, lower MT and higher diastolic blood pressure were associated with lower MT\u2010change (p\u00a0&lt;\u00a00.05). Additionally, MT\u2010change significantly contributed to TD slope in the corresponding sectors (\u03b2\u00a0=\u00a00.41, p\u00a0=\u00a00.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid visual field defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14361","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T06:05:28Z","timestamp":1581401128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open\u2010angle glaucoma, a pilot study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-7048","authenticated-orcid":false,"given":"Naoki","family":"Kiyota","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine Miyagi 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