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The study group consisted of 10 patients without MMC intraoperatively and postoperative DexNP eye drops, and the control group consisted of 10 patients treated with MMC intraoperatively and postoperative Maxidex<jats:sup>\u00ae<\/jats:sup>. The drops were tapered out over 8\u00a0weeks. The main outcome measures were as follows: rates of complete success, that is intraocular pressure (IOP) within target pressures at different time\u2010points without IOP\u2010lowering medication, or reoperation. Secondary outcome measures included the following: relative success rate (with IOP\u2010lowering medications), number of glaucoma medications and reoperations. Patients were followed for 36\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed similar postoperative course and IOP reduction. Intraocular pressures (IOPs) in the DexNP group and in the control group were 25.6 and 24.4\u00a0mmHg, respectively, at baseline. Intraocular pressures (IOPs) were reduced to 13.2 and 14.5\u00a0mmHg at 12\u00a0months, 11.7 and 12.6\u00a0mmHg at 24\u00a0months and 11.7 and 12.1\u00a0mmHg at 36\u00a0months, respectively. There were no statistically significant differences between the groups in absolute (p\u00a0=\u00a00.36) or relative (p\u00a0=\u00a01.0) success rates, number of medications (p\u00a0=\u00a00.71) or reoperations (p\u00a0=\u00a01.0) between the groups at any time\u2010point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DexNP eye drops are effective postoperative treatment following trabeculectomy. The potent anti\u2010inflammatory and antifibrotic effect of DexNP may offer an alternative to mitomycin C in glaucoma surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14370","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T06:45:33Z","timestamp":1582008333000},"page":"607-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Can postoperative dexamethasone nanoparticle eye drops replace mitomycin C in trabeculectomy?"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-4563","authenticated-orcid":false,"given":"Gauti","family":"J\u00f3hannesson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Ophthalmology Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Wallenberg Centre for Molecular Medicine Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Department of Ophthalmology Faculty of Medicine National University Hospital University of Iceland Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-8416","authenticated-orcid":false,"given":"Mar\u00eda Soff\u00eda","family":"Gottfredsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine National University Hospital University of Iceland Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u00f0r\u00fan Marta","family":"\u00c1sgrimsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Oculis ehf. 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