{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:49:53Z","timestamp":1792277393630,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate, using optical coherence tomography\u2010angiography (OCT\u2010A), the vascular features of good bleb function after XEN gel implantation (XGI) for uncontrolled glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three patients (43 eyes), who underwent XGI, were enrolled. According to the intraocular pressure (IOP) reduction, patients were classified into Group 1 (21 eyes; success) and Group 2 (22 eyes; failure). Optical coherence tomography\u2010angiography (OCT\u2010A) was performed to image the vascularization of the conjunctival bleb\u2010wall. The main outcomes were as follows: vessel displacement areas (VDAs), major vessel displacement area (MVDA; mm<jats:sup>2<\/jats:sup>), non\u2010flow whole area (NFWA; mm<jats:sup>2<\/jats:sup>) and bleb\u2010wall vessel density (BVD; %). Co\u2010registered B\u2010scans were also considered to evaluate the bleb\u2010wall cyst\u2010like structure density and area (BCSD, cysts\/mm<jats:sup>2<\/jats:sup>; BCSA, mm<jats:sup>2<\/jats:sup>), and the bleb\u2010wall thickness (BT, \u00b5m).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean postoperative follow\u2010up was 7.5\u00a0\u00b1\u00a00.14\u00a0months; Group 1 and 2 IOP were 14.0\u00a0\u00b1\u00a02.5 and 25.3\u00a0\u00b1\u00a02.1\u00a0mmHg, respectively (p\u00a0&lt;\u00a00.001). Greater VDA (p\u00a0&lt;\u00a00.001), MVDA (p\u00a0=\u00a00.046) and NFWA (p\u00a0=\u00a00.001) values, and lower BVD (p\u00a0&lt;\u00a00.001) was found in Group 1 compared to Group 2. Group 1 showed higher BSCD, BSCA and BT values compared to Group 2 (p\u00a0&lt;\u00a00.001). Postoperative IOP positively correlated with BVD (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.567; p\u00a0=\u00a00.003), but negatively with VDAs, MVDA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.581, p\u00a0=\u00a00.002; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.619, p\u00a0=\u00a00.001, respectively), BCSD, BCSA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.580; p\u00a0=\u00a00.002; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.664; p\u00a0&lt;\u00a00.001) and BT (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.627, p\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Successful filtration blebs after XGI present numerous and large areas of vessel displacement within the bleb\u2010wall, along with a rarefied vascular network. These OCT\u2010A features can be considered angiographic biomarkers of a good aqueous humour percolation through the bleb\u2010wall layers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14371","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T09:33:00Z","timestamp":1580895180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Angiographic biomarkers of filtering bleb function after XEN gel implantation for glaucoma: an optical coherence tomography\u2010angiography study"],"prefix":"10.1111","volume":"98","author":[{"given":"Rodolfo","family":"Mastropasqua","sequence":"first","affiliation":[{"name":"Institute of Ophthalmology University of Modena and Reggio Emilia Modena 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