{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:00:55Z","timestamp":1792101655651,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the concentrations of pro\u2010inflammatory cytokines in tear and aqueous humour of patients with primary open\u2010angle glaucoma (POAG), relative to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Tear and aqueous humour samples were collected from 29 healthy controls and 27 POAG\u00a0patients. Twenty\u2010seven inflammatory cytokines were analysed: interleukin (IL)\u20101\u03b2, IL\u20101ra, IL\u20102, IL\u20104, IL\u20105, IL\u20106, IL\u20107, IL\u20108, IL9, IL\u201010, IL\u201012, IL\u201013, IL\u201015, IL\u201017, eotaxin, fibroblast growth factor (FGF) basic, granulocyte colony\u2010stimulating factor, granulocyte\u2010monocyte colony\u2010stimulating factor, interferon (IFN)\u2010\u03b3, interferon gamma\u2010induced protein, monocyte chemo\u2010attractant protein\u20101, macrophage inflammatory protein (MIP)\u20101\u03b1, MIP\u20101\u03b2, platelet\u2010derived growth factor, regulated on activation normal T cell expressed and secreted, tumour necrosis factor (TNF)\u2010\u03b1 and vascular endothelial growth factor (VEGF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In tear samples of glaucoma patients, an increase in IL\u20104, IL\u201012, IL\u201015, FGF\u2010basic\u00a0and VEGF was observed, as well as a decrease in MIP\u20101a relative to the control group (p\u00a0&lt;\u00a00.05). IL\u20105, IL\u201012, IL\u201015, IFN\u2010\u03b3 and MIP\u20101a were significantly higher in aqueous humour of glaucoma eyes (p\u00a0&lt;\u00a00.05). A poor correlation between cytokine levels in tear and aqueous humour was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The different profiles of inflammatory marker expression of patients with POAG\u00a0and healthy controls confirm the inflammatory activity of the pathology, indicating that some of them could be used as potential biomarkers of this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14374","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T10:56:36Z","timestamp":1581418596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Tear and aqueous humour cytokine profile in primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6164","authenticated-orcid":false,"given":"Barbara","family":"Burgos\u2010Blasco","sequence":"first","affiliation":[{"name":"Servicio de 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