{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:45:53Z","timestamp":1791243953795,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Time is the key criterion in the management of non\u2010arteritic central retinal artery occlusion (NA\u2010CRAO). However, the precise onset of vision loss is often difficult to determine. This study aimed to evaluate the temporal changes of retinal thickness in acute NA\u2010CRAO and the potential of this parameter to be used as a surrogate marker to estimate the onset of retinal ischaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Optical coherence tomography was used to continuously assess retinal thickness and oedema progression rate in six porcine eyes. Additionally, a retrospective analysis of 12 patients with acute NA\u2010CRAO was performed to determine association strength and progression rate between retinal thickness and onset of ischaemia. All Optical coherence tomography (OCT) scans (pigs and NA\u2010CRAO patients) were performed within an ischaemic time frame of up to 9\u00a0hr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Retinal oedema progression rate in pigs was 25.32\u00a0\u00b5m\/hr [CI 95%: 24.24\u201326.40\u00a0\u00b5m\/hr]. Retrospective analysis of the patients revealed a strong correlation between retinal oedema and duration of ischaemia (Spearman's rho\u00a0=\u00a00.77, p\u00a0=\u00a00.004) with an estimated progression rate of 10.02\u00a0\u00b5m\/hr [CI 95%: 3.30\u201316.74\u00a0\u00b5m\/hr].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Retinal thickness increases with oedema formation, and ischaemia onset is strongly correlated with this structural biomarker in both, pigs and NA\u2010CRAO patients. Prospective clinical trials will have to determine the clinical feasibility of retinal thickness measurements as a biomarker to support clinical management of NA\u2010CRAO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14375","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T14:05:09Z","timestamp":1581343509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Retinal oedema in central retinal artery occlusion develops as a function of time"],"prefix":"10.1111","volume":"98","author":[{"given":"G. Alex","family":"Ochakovski","sequence":"first","affiliation":[{"name":"Centre for Ophthalmology University Eye Hospital University Hospital T\u00fcbingen T\u00fcbingen Germany"},{"name":"Institute for Ophthalmic Research Centre for Ophthalmology University Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-3648","authenticated-orcid":false,"given":"Daniel A.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology University Eye Hospital University Hospital T\u00fcbingen T\u00fcbingen Germany"},{"name":"Department of Ophthalmology University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg 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