{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:15:01Z","timestamp":1784304901022,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul National University Bundang Hospital Research Fund, Seoul, South Korea","award":["02-2016-023"],"award-info":[{"award-number":["02-2016-023"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the incidence of parapapillary choroidal microvasculature dropout (MvD) in nonglaucomatous healthy eyes using optical coherence tomography angiography (OCTA) and to characterize the MvD observed in these eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010six eyes (19 eyes with an MvD and 57 age\u2010matched eyes without an MvD) from a cohort of 297 nonglaucomatous healthy eyes that underwent OCTA were included. The peripapillary choroidal microvasculature was evaluated in en\u2010face images obtained using swept\u2010source OCTA. An MvD was defined as a focal sectoral capillary dropout with no visible microvascular network identified in the en\u2010face images of the choroidal layer. The incidence of MvD and clinical characteristics associated with the presence of an MvD was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MvD was found in 19 of the 297 nonglaucomatous healthy eyes (6.4%). Compared with age\u2010matched eyes without an MvD, eyes with an MvD had lower systolic blood pressure (p\u00a0=\u00a00.021), diastolic blood pressure (p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.048), mean arterial pressure (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.025) and mean ocular perfusion pressure (p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.032). Logistic regression analyses showed that cold extremities (p\u00a0=\u00a00.046), lower mean arterial pressure (p\u00a0=\u00a00.021) and lower mean ocular perfusion pressure (p\u00a0=\u00a00.023) were associated with the presence of an MvD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parapapillary choroidal MvD can be present in nonglaucomatous healthy eyes. The presence of an MvD is associated with systemic vascular dysregulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14385","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T04:31:00Z","timestamp":1583123460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Parapapillary choroidal microvasculature dropout in nonglaucomatous healthy eyes"],"prefix":"10.1111","volume":"98","author":[{"given":"Gyu\u2010Nam","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Institute of Health Sciences Gyeongsang National University School of Medicine Gyeongsang National University Hospital Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-9452","authenticated-orcid":false,"given":"Eun Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5180-0978","authenticated-orcid":false,"given":"Tae\u2010Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.06.009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e318255bb4a"},{"key":"e_1_2_5_4_1","first-page":"363","volume-title":"Automated static perimetry","author":"Anderson DR","year":"1999"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903000103"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.1082"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90324-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1964.00970010235017"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309104"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.53.11.721"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.54.7.461"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.02.049"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212949"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/0471722146","volume-title":"Applied logistic regression","author":"Hosmer DW","year":"2000"},{"key":"e_1_2_5_15_1","unstructured":"JeffreyL(2015):The role of ocular perfusion pressure in glaucoma. 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