{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:12:04Z","timestamp":1789607524752,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010669","name":"H2020 LEIT Information and Communication Technologies","doi-asserted-by":"publisher","award":["780989"],"award-info":[{"award-number":["780989"]}],"id":[{"id":"10.13039\/100010669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A growing number of studies have reported a link between vascular damage and glaucoma based on optical coherence tomography angiography (OCTA) imaging. This multitude of studies focused on different regions of interest (ROIs) which offers the possibility to draw conclusions on the most discriminative locations to diagnose glaucoma. The objective of this work was to review and analyse the discriminative capacity of vascular density, retrieved from different ROIs, on differentiating healthy subjects from glaucoma patients. PubMed was used to perform a systematic review on the analysis of glaucomatous vascular damage using OCTA. All studies up to 21 April 2019 were considered. The ROIs were analysed by region (macula, optic disc and peripapillary region), layer (superficial and deep capillary plexus, avascular, whole retina, choriocapillaris and choroid) and sector (according to the Garway\u2013Heath map). The area under receiver operator characteristic curve (AUROC) and the statistical difference (p\u2010value) were used to report the importance of each ROI for diagnosing glaucoma. From 96 screened studies, 43 were eligible for this review. Overall, the peripapillary region showed to be the most discriminative region with the highest mean AUROC (0.80\u00a0\u00b1\u00a00.09). An improvement of the AUROC from this region is observed when a sectorial analysis is performed, with the highest AUROCs obtained at the inferior and superior sectors of the superficial capillary plexus in the peripapillary region (0.86\u00a0\u00b1\u00a00.03 and 0.87\u00a0\u00b1\u00a00.10, respectively). The presented work shows that glaucomatous vascular damage can be assessed using OCTA, and its added value as a complementary feature for glaucoma diagnosis depends on the region of interest. A sectorial analysis of the superficial layer at the peripapillary region is preferable for assessing glaucomatous vascular damage.<\/jats:p>","DOI":"10.1111\/aos.14392","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T04:45:54Z","timestamp":1584420354000},"page":"537-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions"],"prefix":"10.1111","volume":"98","author":[{"given":"Amerens","family":"Bekkers","sequence":"first","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Clinical Technology Delft University of Technology Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Borren","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Clinical Technology Delft University of Technology Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Ederveen","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Clinical Technology Delft University of Technology Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Fokkinga","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Clinical Technology Delft University of Technology Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-4163","authenticated-orcid":false,"given":"Danilo","family":"Andrade De Jesus","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Research Group Ophthalmology Department of Neurosciences KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-4846","authenticated-orcid":false,"given":"Luisa","family":"S\u00e1nchez Brea","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Klein","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"van Walsum","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Group Rotterdam Department of Radiology &amp; Nuclear Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-816X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Barbosa\u2010Breda","sequence":"additional","affiliation":[{"name":"Research Group Ophthalmology Department of Neurosciences KU Leuven Leuven Belgium"},{"name":"Ophthalmology Department Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o Porto Portugal"},{"name":"Cardiovascular R&amp;D Center Faculty of Medicine of the University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Stalmans","sequence":"additional","affiliation":[{"name":"Research Group Ophthalmology Department of Neurosciences KU Leuven Leuven Belgium"},{"name":"Department of Ophthalmology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12962"},{"key":"e_1_2_5_3_1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abr\u00e0moff MD","year":"2004","journal-title":"Biophotonics Int"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170476"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3865-9"},{"key":"e_1_2_5_6_1","article-title":"AngioOCT peripapillary microvascular density outperforms standard OCT parameters as a discriminant between different glaucoma severity levels\u2013The Leuven Eye Study","volume":"59","author":"Barbosa\u2010Breda J","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13809"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13942"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154691"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3709-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18909"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21846"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20709"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2017.1337157"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-015-0192-6"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189237"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18287"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00284-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309642"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(01)00012-8"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14193"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177180"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0207-z"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.004710"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.021"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00658-9"},{"key":"e_1_2_5_28_1","first-page":"1","article-title":"Comparison of peripapillary vessel density between preperimetric and perimetric glaucoma evaluated by OCT\u2010angiography","volume":"12","author":"Kim SB","year":"2017","journal-title":"PLoS ONE"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13639"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309389"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13914"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19984"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201599"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000800"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25864"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2225"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22021"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3965-1"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000649"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199604000-00004"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.09.019"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001165"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2018.02.004"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205773"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.08.030"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309377"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.02.020"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000758"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173930"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489457"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9132700"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18945"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3671-4"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.12.026"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000765"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02178.x"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442771"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01586.x"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.06.002"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22865"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488495"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.2.026001"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3930-z"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18944"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.08.041"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.004"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001125"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.001919"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000900"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8923819"}],"updated-by":[{"DOI":"10.1111\/aos.14481","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000}}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.14392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:54:52Z","timestamp":1693907692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/aos.14392"],"URL":"https:\/\/doi.org\/10.1111\/aos.14392","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1111\/aos.14481","asserted-by":"object"}]},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2019-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}