{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:26:43Z","timestamp":1783636003794,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009399","name":"Macular Disease Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess whether dietary intake of antioxidants, fruits, vegetables and fish is associated with 12\u2010month treatment outcomes in neovascular age\u2010related macular degeneration (nAMD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 547 participants were diagnosed with nAMD at baseline, of whom 494 were followed up after 12\u00a0months of antivascular endothelial growth factor therapy. Dietary intakes were determined using a validated food frequency questionnaire. Presence of intra\u2010retinal and sub\u2010retinal fluid (IRF, SRF), pigment epithelial detachment (PED) and central macular thickness (CMT) were recorded from optical coherence tomography images. Best\u2010corrected visual acuity was recorded using log of the Minimum Angle of Resolution (LogMAR) charts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants in the upper three quartiles combined compared to those in the first quartile of baseline dietary zinc intake had 49% reduced odds of SRF 12\u00a0months later, multivariable\u2010adjusted odds ratio (OR) 0.51 [95% confidence interval (CI) 0.30\u20100.89]. The upper three quartiles combined compared to the first quartile of \u03b2\u2010carotene intake had 90% greater odds of IRF presence at 12\u2010month follow\u2010up, multivariable\u2010adjusted OR 1.90 (95% CI 1.04\u20103.46). The highest versus lowest quartile of dietary \u03b2\u2010carotene intake had a nearly twofold greater odds of PED presence, multivariable\u2010adjusted OR 1.99 (95% CI 1.03\u20103.84).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A higher intake of dietary zinc was associated with a reduced likelihood of SRF at 1\u00a0year. Conversely, a higher intake of dietary \u03b2\u2010carotene was associated with an increased risk of IRF and PED. These findings underscore the importance of ongoing nutritional advice for nAMD patients presenting for treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14394","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T07:23:21Z","timestamp":1583997801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary antioxidants are associated with presence of intra\u2010 and sub\u2010retinal fluid in neovascular age\u2010related macular degeneration after 1\u00a0year"],"prefix":"10.1111","volume":"98","author":[{"given":"Harshil","family":"Dharamdasani Detaram","sequence":"first","affiliation":[{"name":"Centre for Vision Research Department of Ophthalmology and The Westmead Institute for Medical Research The University of Sydney Sydney New South Wales 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