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However, the decreased metabolic activity of atrophic tissue is itself known to induce both vascular changes and decreased blood flow due to reduced oxygen demand. Therefore, primary nonvascular factors could potentially induce glaucomatous atrophy, with subsequent secondary vascular pathology (\u2018mechanical hypothesis\u2019). Retinal oximetry holds great promise in the investigation of glaucoma pathogenesis, as it can provide useful data on retinal metabolic oxygen demand, especially when combined with measurements of retinal blood flow. This review surveys the research on retinal metabolism in POAG using spectroscopic retinal oximetry. The use of mathematical models in combination with oximetric data to investigate the role of retinal metabolism and oxygen supply in POAG is also discussed.<\/jats:p>","DOI":"10.1111\/aos.14397","type":"journal-article","created":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T18:04:10Z","timestamp":1586109850000},"page":"559-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Retinal oximetry in glaucoma: investigations and findings reviewed"],"prefix":"10.1111","volume":"98","author":[{"given":"Aumer","family":"Shughoury","sequence":"first","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute Department of Ophthalmology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunu","family":"Mathew","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute Department of Ophthalmology Indiana University 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