{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:29:08Z","timestamp":1790303348647,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Since histomorphometric descriptions of posterior scleral staphylomas, although forming a major part of myopic maculopathy, have been scarce so far, we histomorphometrically examined scleral staphylomas in enucleated human eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using light microscopy, we histomorphometrically examined sagittal histological sections of human globes enucleated due to malignant choroidal melanomas or secondary angle\u2010closure glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 246 globes included into the study, posterior scleral staphylomas were detected in 10 eyes (mean length: 31.4\u00a0\u00b1\u00a03.0\u00a0mm; range: 28.0\u201337.0\u00a0mm). In the staphylomatous region in the study group as compared with the corresponding region of a control group adjusted for age and axial length, scleral thickness was significantly lower (109\u00a0\u00b1\u00a025\u00a0\u00b5m versus 319\u00a0\u00b1\u00a0161\u00a0\u00b5m; p\u00a0=\u00a00.001). The study group in the staphylomatous region as compared to the highly myopic control group in the corresponding region did not differ significantly in retinal pigment epithelium (RPE) cell density (19.6\u00a0\u00b1\u00a04.9 cells\/300\u00a0\u00b5m versus 21.1\u00a0\u00b1\u00a05.7 cells\/300\u00a0\u00b5m; p\u00a0=\u00a00.84) and RPE height (8.2\u00a0\u00b1\u00a02.8\u00a0\u00b5m versus 6.1\u00a0\u00b1\u00a02.5\u00a0\u00b5m; p\u00a0=\u00a00.13), Bruch\u2019s membrane (BM) thickness (3.5\u00a0\u00b1\u00a01.3\u00a0\u00b5m versus 4.2\u00a0\u00b1\u00a02.3\u00a0\u00b5m; p\u00a0=\u00a00.40) and choriocapillaris thickness (5.3\u00a0\u00b1\u00a02.8\u00a0\u00b5m versus 4.4\u00a0\u00b1\u00a02.8\u00a0\u00b5m; p\u00a0=\u00a00.49) and density (164\u00a0\u00b1\u00a099\u00a0\u00b5m versus 226\u00a0\u00b1\u00a038\u00a0\u00b5m; p\u00a0=\u00a00.13). All staphylomatous regions showed a localized BM defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Marked scleral thinning and spatially correlated BM defects histologically characterized myopic scleral staphylomas, while thickness and density of the choriocapillaris and RPE and BM thickness did not differ significantly between staphylomatous versus non\u2010staphylomatous eyes in the respective regions. These findings support the notion that a locally reduced scleral resistance against a backward pushing BM led to a local scleral outpouching. The outpouching\u2010associated increase in curvature length may stretch BM with the sequel of a localized BM rupture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14405","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:04:33Z","timestamp":1584619473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Histology of myopic posterior scleral staphylomas"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Ohno\u2010Matsui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Holbach","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182080"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43212-8"},{"key":"e_1_2_5_4_1","article-title":"Prevalence and time trends of myopia in children and adolescents in China: a 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