{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:29:41Z","timestamp":1769585381098,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Youth Clinical Research Project of Peking University First Hospital","award":["2019CR01"],"award-info":[{"award-number":["2019CR01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the morphological characteristics of the nailfold capillaries in glaucoma patients with those in healthy subjects. To evaluate the relationship of nailfold capillary morphology with retinal thickness and retinal vessel density in patients with primary open\u2010angle (POAG) and primary angle\u2010closure glaucoma (PACG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one patients with normal\u2010tension glaucoma, thirty\u2010two patients with hypertension glaucoma, thirty\u2010two PACG patients and sixty\u2010one healthy subjects were included in this cross\u2010sectional study. Patients with connective tissue diseases or taking anticoagulation or antiplatelet agents were excluded. Nailfold capillaroscopy, spectral\u2010domain optical coherence tomography and optical coherence tomography angiography were used to evaluate the nailfold capillary morphology, retinal thickness and retinal vessel density, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nailfold capillary morphological features, including lower capillary density, greater tortuosity, more dilated capillaries &gt;50\u00a0\u03bcm and more avascular zones &gt;100\u00a0\u03bcm, were more common in POAG and PACG patients than in control subjects (all p\u00a0&lt;\u00a00.001). In the POAG group, nailfold vessel density was negatively correlated with ganglion cell complex (GCC) thickness (odds ratio [OR]\u00a0=\u00a00.908, p\u00a0=\u00a00.010) and radial peripapillary capillary (RPC) density (OR\u00a0=\u00a00.787, p\u00a0=\u00a00.025). Tortuosity degree was negatively associated with RPC density (OR\u00a0=\u00a00.804, p\u00a0=\u00a00.016). In the PACG group, no evident relationship between nailfold capillary morphology and retinal thickness or retinal vessel density was detected (all p<jats:italic>\u00a0<\/jats:italic>&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nailfold capillary bed abnormalities were observed in both POAG and PACG patients. The nailfold capillary features, especially microvascular density and tortuosity degree, had a significant association with GCC thickness and RPC density in subjects with POAG but not in those with PACG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14416","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T19:00:22Z","timestamp":1585940422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between nailfold capillary morphology and retinal thickness and retinal vessel density in primary open\u2010angle and angle\u2010closure glaucoma"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-4808","authenticated-orcid":false,"given":"Xin","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25421"},{"key":"e_1_2_5_3_1","first-page":"29","article-title":"Capillarosecopic patterns in rheumatic diseases","volume":"32","author":"Cortes S","year":"2007","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12298"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.312"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-311846"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.032110"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01573.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-017-0090-x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-4-14"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000159"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-114"},{"key":"e_1_2_5_13_1","first-page":"238","article-title":"Clinical applications of nailfold capillaroscopy in different rheumatic diseases","volume":"20","author":"Kin KMCT","year":"2009","journal-title":"J Intern Med"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-5-11"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-017-0097-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32831eef82"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2225"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.06.008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2795-8"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20141118-04"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.249"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17860"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309377"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.02.020"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310180"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.026"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.12.007"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310637"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312401"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.14416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T21:48:45Z","timestamp":1693604925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,3]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/aos.14416"],"URL":"https:\/\/doi.org\/10.1111\/aos.14416","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,3]]},"assertion":[{"value":"2019-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}