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Three validated instruments measuring HR\u2010QoL and VR\u2010QoL were used: The Pediatric QoL Inventory (PedsQL), consisting of physical and psychosocial self\u2010report and parent\u2010proxy report (2\u201318\u00a0years); Children\u2019s Visual Function Questionnaire (CVFQ); and Effects of Youngsters\u2019 Eyesight on Quality of Life (EYE\u2010Q). Perceptual visual dysfunctions (PVDs) were assessed by history taking according to a specific protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A\/M children and their parents showed low HR\u2010QoL scores (PedsQL total score: 66.3; 69.6) compared with controls (83.0; 87.61) (p\u00a0=\u00a00.0035 and &lt;0.0001, respectively, unpaired <jats:italic>t<\/jats:italic>\u2010test). No differences were found between A\/M children and parents, but parents tended to underestimate their children\u2019s emotional state. A\/M children with subnormal visual acuity (VA) for age scored lower in physical health compared with A\/M children with normal VA (p\u00a0=\u00a00.03, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test). No significant VR\u2010QoL differences between A\/M children and references or between A\/M children with subnormal or normal VA for age were found. More A\/M children than controls exhibited PVDs in \u22651 area (7\/11 versus 4\/118; p\u00a0&lt;\u00a00.0001, Fisher\u2019s exact test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A\/M individuals show poor HR\u2010QoL and increased PVDs. No difference in QoL was found between children and parents, though the children tended to score lower in emotional well\u2010being. A\/M children with subnormal VA showed lower physical health score. These problems indicate the necessity of a thorough multidisciplinary assessment and follow\u2010up of children with A\/M.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14424","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T04:14:45Z","timestamp":1588306485000},"page":"662-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Visual function and quality of life in children and adolescents with anophthalmia and microphthalmia treated with ocular prosthesis"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-7105","authenticated-orcid":false,"given":"Beatrice","family":"Cassl\u00e9n","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg 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