{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:19:01Z","timestamp":1768274341179,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to determine whether choroidal thickness (CT) increases at the time of exudative recurrence in diabetic patients with unilateral diabetic macular oedema (DME) treated with intravitreal injections of anti\u2010VEGF or dexamethasone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A real\u2010life, prospective, two\u2010centre study was conducted over a 9\u2010month period investigating diabetic patients presenting with unilateral DME treated with anti\u2010VEGF or dexamethasone intravitreal injections, and CT was measured manually, using the enhanced depth imaging module of the spectral domain optical coherence tomography. Choroidal thickness (CT) was measured in the morning, in both the affected and healthy eye of each patient at two timepoints: when the macula was \u2018dry\u2019 (T0) and at the time of exudative recurrence (T1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51 patients with unilateral DME were included. Mean CT in the affected eye was significantly thicker at the time of exudative recurrence (210.8\u00a0\u00b1\u00a044.1\u00a0\u03bcm at T0 versus 238.0\u00a0\u00b1\u00a049.0\u00a0\u03bcm at T1, p\u00a0&lt;\u00a00.001). There was no significant variation in CT in the fellow eye (214.4\u00a0\u00b1\u00a052.3\u00a0\u00b5m at T0 versus 218.9\u00a0\u00b1\u00a053.4\u00a0\u00b5m at T1, p\u00a0=\u00a00.53). The type of intravitreal injection, the number of injections and the CT at T0 had no influence on the change in CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found that CT increased significantly in the affected eye at the time of recurrence of DME treated with anti\u2010VEGF or dexamethasone injections. Choroidal thickness (CT) could constitute an interesting new indicator for monitoring patients with DME.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14447","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T11:33:33Z","timestamp":1587123213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased choroidal thickness: a new indicator for monitoring diabetic macular oedema recurrence"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-1872","authenticated-orcid":false,"given":"Thibaud","family":"Mathis","sequence":"first","affiliation":[{"name":"Service d\u2019ophtalmologie H\u00f4pital de la Croix Rousse Lyon France"},{"name":"UMR\u2010CNRS 5510 Mat\u00e9is Villeurbanne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Mendes","sequence":"additional","affiliation":[{"name":"Service 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