{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:26:54Z","timestamp":1783466814058,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sensimed AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the use of a 24\u2010hr ocular dimensional profile recorded with a contact lens sensor (CLS) combined with a single tonometric intraocular pressure (IOP) reading to indicate the potential for exceeding the diagnostic threshold for normal tension glaucoma (NTG) in Japanese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intraocular pressure (IOP) of untreated Japanese NTG patients was measured with tonometry every 3\u00a0hr from 9:00 to 24:00. The subsequent day a 24\u2010hr CLS (SENSIMED Triggerfish, Sensimed AG, Lausanne, Switzerland) profile was recorded on the same eye. Patients initially diagnosed as NTG were reclassified as NTG when the measured IOP values were consistently &lt;20\u00a0mmHg or as primary open\u2010angle glaucoma (POAG) when IOP was \u226520\u00a0mmHg in at least 1 measurement. For each patient and each IOP time\u2010point, IOP values were combined with information provided by the CLS profile (\u2018classifier\u2019) to indicate the potential for exceeding the diagnostic threshold value. Statistical analyses were performed for each classifier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 65 patients, 28 males and 37 females (mean ages: 50.8\u00a0\u00b1\u00a014.6\u00a0years and 52.6\u00a0\u00b1\u00a010.2\u00a0years, respectively), were analysed. Following IOP diurnal measurement, five patients (7.7%) were reclassified as POAG. Two classifiers (15:00 CLS and 18:00 CLS) showed high sensitivity and negative predictive value (100%), identifying all the POAG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contact lens sensor information can be used in conjunction with a single tonometric reading to determine patients\u2019 potential of having IOP levels exceeding the diagnostic threshold within a 24\u2010hr period, without the need to perform a 24\u2010hr tonometric curve. This would allow clinicians to identify POAG patients who may otherwise be eventually misclassified as NTG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14453","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T20:17:05Z","timestamp":1588018625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Using 24\u2010hr ocular dimensional profile recorded with a sensing contact lens to identify primary open\u2010angle glaucoma patients with intraocular pressure constantly below the diagnostic threshold"],"prefix":"10.1111","volume":"98","author":[{"given":"Satomi","family":"Shioya","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science Kanazawa University Graduate School of Medical Science Kanazawa 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