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The aim of this study was to investigate RO parameters of children with IRDs and presumed IRD carriers (pIRDc) and to compare them to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional cohort study, 142 eyes from 71 Caucasian subjects were included: 40 eyes with IRDs, 26 eyes with pIRDc and 76 control eyes. The oxygen saturation was measured with the Retinal Vessel Analyser (IMEDOS Systems UG, Jena, Germany). Mean oxygen saturations in the peripapillary retinal arterioles (A\u2010SO<jats:sub>2<\/jats:sub>; %) and venules (V\u2010SO<jats:sub>2<\/jats:sub>; %) were estimated, and their difference (A\u2010V SO<jats:sub>2<\/jats:sub>; %) was calculated. In addition, we evaluated the mean diameter in all major retinal arterioles (D\u2010A; <jats:italic>\u03bc<\/jats:italic>m) and venules (D\u2010V; <jats:italic>\u03bc<\/jats:italic>m). <jats:sc>anova<\/jats:sc>\u2010based linear mixed\u2010effects models were calculated with SPSS<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In general, children suffering from IRDs differed from controls when the A\u2010SO<jats:sub>2<\/jats:sub> and A\u2010V SO<jats:sub>2<\/jats:sub> were taken into account: both the A\u2010SO<jats:sub>2<\/jats:sub> and the A\u2010V SO<jats:sub>2<\/jats:sub> were significantly increased (p\u00a0=\u00a00.012). In subgroup analyses, children suffering from rod\u2013cone dystrophy (RCD) presented an A\u2010SO<jats:sub>2<\/jats:sub> increase (99.12\u00a0\u00b1\u00a08.24%) when compared to controls (91.33\u00a0\u00b1\u00a010.34%, p\u00a0=\u00a00.014) and pIRDc (92.37\u00a0\u00b1\u00a06.57%, p\u00a0=\u00a00.065). For V\u2010SO<jats:sub>2<\/jats:sub> significant changes in RCD (67.42\u00a0\u00b1\u00a09.19%) were found in comparison with controls (58.24\u00a0\u00b1\u00a011.74%, p\u00a0&lt;\u00a00.041), pIRDc (56.67\u00a0\u00b1\u00a07.16%, p\u00a0=\u00a00.007), cone\u2013rod dystrophies (CRD, 52.17\u00a0\u00b1\u00a05.32%, p\u00a0&lt;\u00a00.001) and inherited macular dystrophies (IMD, 55.74\u00a0\u00b1\u00a06.96%, p\u00a0=\u00a00.004), In addition, A\u2010V SO<jats:sub>2<\/jats:sub> was decreased in RCD (31.69\u00a0\u00b1\u00a03.92%) when measured against CRD (41.9\u00a0\u00b1\u00a08.87%, p\u00a0=\u00a00.017) or IMD (39.52\u00a0\u00b1\u00a08.95%, p\u00a0=\u00a00.059).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In general, we found that children with IRDs presented early metabolic changes. Within IRDs, children with RCD showed more affected metabolic changes. Thus, RO may support early screening to rule out IRDs in children, and more precisely may help to differentiate those suffering from RCD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14466","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T06:43:40Z","timestamp":1592894620000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinal vessel oximetry in children with inherited retinal diseases"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-4842","authenticated-orcid":false,"given":"Maria","family":"della Volpe Waizel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Basel Basel Switzerland"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel (IOB) Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik P. 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