{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:31:12Z","timestamp":1774438272510,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Ultrasound cycloplasty (UCP) acts through the selective coagulation of the ciliary body using high\u2010intensity focused ultrasound (HIFU) technology. The aim of this study was to investigate whether the application of ultrasound beams targeting the ciliary body using an external probe influences astigmatism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre, prospective, single\u2010arm, open\u2010label study in adult patients with primary open\u2010angle glaucoma and moderately uncontrolled intraocular pressure (IOP) under glaucoma medication. The primary outcome was induced corneal astigmatism, calculated from topography, and assessed statistically through vector analysis. Secondary outcomes included induced total astigmatism and mean changes from baseline in best\u2010corrected visual acuity (logMAR) and IOP. Subgroup analysis was performed to assess the impact of device centring on corneal and total induced astigmatism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty eyes were enrolled. Mean age was 69.6\u00a0\u00b1\u00a011.3\u00a0years. At 1, 3 and 6\u00a0months postprocedure, HIFU\u2010induced corneal astigmatism was 0.88\u00a0D\u00a0\u00d7\u00a093\u00b0, 0.87\u00a0D\u00a0\u00d7\u00a0106\u00b0 and 1.16\u00a0D\u00a0\u00d7\u00a097\u00b0, respectively, while induced total astigmatism was 0.62\u00a0D\u00a0\u00d7\u00a0103\u00b0, 0.42\u00a0\u00d7\u00a0106\u00b0 and 0.39\u00a0\u00d7\u00a0107\u00b0. By the last follow\u2010up, the percentage of patients with &lt;0.50, &lt;1.00, &lt;1.50 and &lt;2.00\u00a0D of induced corneal versus total astigmatism was 8.3% versus 46%, 29% versus 66%, 62.5% versus 88% and 79% versus 94%. Visual acuity was statistically significantly impaired at 1\u00a0month, but no difference remained by 3 and 6\u00a0months postprocedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasound cycloplasty procedure is associated with increased corneal astigmatism. However, its impact on total refractive astigmatism is less pronounced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14467","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T18:56:46Z","timestamp":1589828206000},"page":"833-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of glaucoma treatment using high\u2010intensity focused ultrasound on total and corneal astigmatism: a prospective multicentre study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-7592","authenticated-orcid":false,"given":"Raquel Esteves","family":"Marques","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Hospital de Santa Maria Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"},{"name":"Vision Sciences Study Centre CECV Faculdade de Medicina Universidade de Lisboa Lisboa 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