{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:58:58Z","timestamp":1790207938648,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012331","name":"Agentschap Innoveren en Ondernemen","doi-asserted-by":"publisher","award":["HBC.5016.0250"],"award-info":[{"award-number":["HBC.5016.0250"]}],"id":[{"id":"10.13039\/100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1S41517N"],"award-info":[{"award-number":["1S41517N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","award":["O&O 145046"],"award-info":[{"award-number":["O&O 145046"]}],"id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the safety and feasibility of robot\u2010assisted retinal vein cannulation with Ocriplasmin infusion for central retinal vein occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective phase I trial including four patients suffering from central retinal vein occlusion (CRVO). Diagnosis was confirmed by preoperative fluo\u2010angiography and followed by a standard three\u2010port pars plana vitrectomy. Afterwards, a custom\u2010built microneedle was inserted into a branch retinal vein with robotic assistance and infusion of Ocriplasmin started. Primary outcomes were the occurrence of intra\u2010operative complications and success of cannulation. Secondary outcomes were change in visual acuity, central macular thickness (CMT) and venous filling times (VFT) during fluo\u2010angiography two weeks after the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cannulation with infusion of ocriplasmin was successful in all four eyes with a mean total infusion time of 355\u00a0\u00b1\u00a0204\u00a0seconds (range 120\u2013600\u00a0seconds). Best corrected visual acuity (BCVA) remained counting fingers (CF) in case 3 and 4, increased in case 1 from CF to 0.9LogMAR and decreased in case 2 from 0.4 to 1.3 LogMAR. CMT and VFT both showed a trend towards significant decrease comparing preoperative measurements with two weeks postintervention (1061\u00a0\u00b1\u00a0541\u00a0\u03bcm versus 477\u00a0\u00b1\u00a0376\u00a0\u03bcm, p\u00a0=\u00a00.068) and 24\u00a0ll\u00a04\u00a0seconds versus 15\u00a0\u00b1\u00a01\u00a0seconds, p\u00a0=\u00a00.068, respectively). In one eye a needle tip broke and could be removed with an endoforceps. There were no other intervention\u2010related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Robot\u2010assisted retinal vein cannulation is feasible and safe. Local intravenous infusion with Ocriplasmin led to an improved retinal circulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14480","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T09:20:32Z","timestamp":1595496032000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Phase I trial on robot assisted retinal vein cannulation with ocriplasmin infusion for central retinal vein occlusion"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-6610","authenticated-orcid":false,"given":"Koen","family":"Willekens","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Gijbels","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Schoevaerdts","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Blanckaert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean H. 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