{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:02:09Z","timestamp":1787317329387,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Axial myopia is characterized by a thinning of the choroid. We examined whether the myopic choroidal thinning also includes a thinning of the choriocapillaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using light microscopy, we measured thickness and density of the choriocapillaris at the posterior pole, posterior pole\u2013equator midpoint (PPEMP), equator and close to the ora serrata on histological sections of 58 enucleated human globes (mean age: 62.4\u00a0\u00b1\u00a017.8\u00a0years; range: 24\u201388\u00a0years; mean axial length: 27.8\u00a0\u00b1\u00a04.0\u00a0mm; range: 22.0\u201337.0\u00a0mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Choriocapillaris thickness decreased (p\u00a0&lt;\u00a00.001) from the posterior pole (median: 3.9\u00a0\u00b5m; interquartile range (IQR): 3.3\u20136.0) to the equator (median: 2.7\u00a0\u00b5m; IQR: 1.5, 4.2). It was not significantly associated with axial length, neither at the posterior pole (p\u00a0=\u00a00.25), the PPEMP (p\u00a0=\u00a00.81), equator (p\u00a0=\u00a00.80) or ora serrata (p\u00a0=\u00a00.50). Mean choriocapillaris density decreased from the posterior pole to the equator (198\u00a0\u00b5m\/300\u00a0\u00b5m; IQR: 152\/300, 246\/300 versus 156\u00a0\u00b5m\/300\u00a0\u00b5m; IQR: 72\/300, 216\/300; p\u00a0&lt;\u00a00.001). Choriocapillaris density was not significantly associated with axial length (posterior pole: p\u00a0=\u00a00.07; PPEMP: p\u00a0=\u00a00.33; equator: p\u00a0=\u00a00.22; ora serrata: p\u00a0=\u00a00.36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The choriocapillaris thickness and density, decreasing from the posterior pole to the fundus periphery, were not significantly associated with axial length. These findings may be of interest for the understanding of high myopia and pathologic myopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14486","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T01:31:35Z","timestamp":1592616695000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Choriocapillaris thickness and density in axially elongated eyes"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-863X","authenticated-orcid":false,"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Holbach","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht\u2010Karls\u2010University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21289"},{"key":"e_1_2_5_3_1","first-page":"1085","article-title":"The Alabama age\u2010related macular degeneration grading system for donor eyes","volume":"39","author":"Curcio CA","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21229"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099690"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.01.012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.029"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13084"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39653-w"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.006"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11352"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12372"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136833"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138701"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13188"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001464"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13537"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.01.035"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013571"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.022"},{"key":"e_1_2_5_21_1","first-page":"2857","article-title":"Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan RS","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.11.021"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309628"},{"key":"e_1_2_5_24_1","volume-title":"Ryan's Retina","author":"Schachat AP","year":"2017"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20190503-13"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.3519"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.023"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.032"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.1627"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.048"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002233"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22745-4"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T17:33:59Z","timestamp":1693676039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/aos.14486"],"URL":"https:\/\/doi.org\/10.1111\/aos.14486","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]},"assertion":[{"value":"2020-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}