{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:04:33Z","timestamp":1784696673961,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Compare patients treated for Retinopathy of Prematurity (ROP) in two consecutive periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective inventory of anonymized neonatal and ophthalmological data of all patients treated for ROP from 2010 to 2017 in the Netherlands, subdivided in period (P)1: 1\u20101\u20102010 to 31\u20103\u20102013 and P2: 1\u20104\u20102013 to 31\u201012\u20102016. Treatment characteristics, adherence to early treatment for ROP (ETROP) criteria, outcome of treatment and changes in neonatal parameters and policy of care were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall 196 infants were included, 57 infants (113 eyes) in P1 and 139 (275 eyes) in P2, indicating a 2.1\u2010fold increase in ROP treatment. No differences were found in mean gestational age (GA) (25.9\u00a0\u00b1\u00a01.7 versus 26.0\u00a0\u00b1\u00a01.7\u00a0weeks, p\u00a0=\u00a00.711), mean birth weight (791\u00a0\u00b1\u00a0311 versus 764\u00a0\u00b1\u00a0204 grams, p\u00a0=\u00a00.967) and other neonatal risk factors for ROP. In P2, the number of premature infants born &lt;25\u00a0weeks increased by factor 1.23 and higher oxygen saturation levels were aimed at in most centres. At treatment decision, 59.6% (P1) versus 83.5% (P2) (p\u00a0=\u00a00.263) infants were classified as Type 1 ROP (ETROP classification). Infants were treated with laser photocoagulation (98 versus 96%) and intravitreal bevacizumab (2 versus 4%). Retreatment was necessary in 10 versus 21 (p\u00a0=\u00a00.160). Retinal detachment developed in 6 versus 13 infants (p\u00a0=\u00a00.791) of which 2 versus 6 bilateral (p\u00a0=\u00a00.599).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In period 2, the number of infants treated according to the ETROP criteria (Type 1) increased, the number of ROP treatments, retinal detachments and retreatments doubled and the absolute number of retinal detachments increased. Neonatal data did not provide a decisive explanation, although changes in neonatal policy were reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14501","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T13:21:31Z","timestamp":1595510491000},"page":"97-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-6746","authenticated-orcid":false,"given":"Kasia","family":"Trzcionkowska","sequence":"first","affiliation":[{"name":"Leiden University Medical Center Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-6397","authenticated-orcid":false,"given":"Wouter 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