{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:30:23Z","timestamp":1792449023200,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the risk of keratoconus (KCN) in patients with atopic keratoconjunctivitis (AKC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This nationwide, retrospective, matched cohort study included 186\u00a0202 newly diagnosed AKC patients who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD\u20109\u2010CM), code 372.05, and selected from the Taiwan National Health Insurance Research Database. The age\u2010 and sex\u2010matched control group included 186\u00a0202 non\u2010AKC patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Patient information was collected between 1 January 2004 and 31 December 2011, and both groups of patients were tracked from the index date until December 2013. The incidence and risk of KCN (ICD\u20109\u2010CM, code 371.6) were compared between the groups. A Cox proportional hazard regression analysis was performed to obtain the adjusted hazard ratio (HR) for KCN. The cumulative KCN incidence rate was calculated with the Kaplan\u2010Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 62 AKC patients and 26 controls developed KCN during the follow\u2010up period. The incidence rate of KCN was 2.49 times (95% confidence interval [CI]\u00a0=\u00a01.57\u20133.93; p\u00a0&lt;\u00a00.0001) higher in AKC patients than in controls. After adjusting for potential confounders, AKC patients were 2.25 times more likely to develop KCN than controls (adjusted HR, 2.25; 95% CI\u00a0=\u00a01.41\u20133.58; p\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Atopic keratoconjunctivitis (AKC) patients had an increased risk of developing KCN. Therefore, AKC patients should be advised of this risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14509","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T07:05:22Z","timestamp":1592809522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between atopic keratoconjunctivitis and the risk of keratoconus"],"prefix":"10.1111","volume":"99","author":[{"given":"Shih\u2010Feng","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Healthcare Administration and Medical Informatics College of Health Sciences Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Center for Medical informatics and Statistics Office of R&amp;D Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-7621","authenticated-orcid":false,"given":"Ren\u2010Long","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chi Mei Medical Center, Liouying Tainan Taiwan"},{"name":"Graduate Institute of Medical Science College of Health Science Chang Jung Christian University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhi\u2010Joung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chi Mei Medical Center Tainan Taiwan"},{"name":"Department of Anesthesiology Chi Mei Medical Center Tainan Taiwan"},{"name":"AI Biomed Center Southern Taiwan University of Science and Technology Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Ophthalmology Chi Mei Medical Center Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-5050","authenticated-orcid":false,"given":"Yuh\u2010Shin","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Science College of Health Science Chang Jung Christian University Tainan Taiwan"},{"name":"Department of Ophthalmology Chi Mei Medical Center Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318172fbb1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13961"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713680903477824"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12038"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.333"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000571"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00570.x"},{"key":"e_1_2_5_9_1","first-page":"425","article-title":"Modification of prostaglandin E2 and collagen synthesis in keratoconus fibroblasts, associated with an increase of interleukin 1 alpha receptor number. 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