{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:00:45Z","timestamp":1788548445650,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The effectiveness and safety of surgery for spheno\u2010orbital meningiomas remains subject of debate, as studies often describe different surgical approaches and reconstruction techniques with very heterogeneous outcomes. We aimed to systematically summarize and analyse the literature on spheno\u2010orbital meningiomas regarding presenting symptoms, surgical techniques, outcomes and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies were retrieved from eight databases. Original articles were included if in \u22655 patients presenting symptoms, surgical treatment and outcomes were described. Fixed\u2010 and random\u2010effects meta\u2010analysis was performed to estimate weighted percentages with 95%CIs of presenting symptoms, outcomes and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight articles were included describing 1486 patients. Proptosis was the most common presenting symptom (84%; 95%CI 76\u201391%), followed by unilateral visual acuity deficits (46%; 95%CI 40\u201351%) and visual field deficits (31%; 95%CI 20\u201343%). In 35\/38 studies (92%), a pterional craniotomy was used. Decompression of the optic canal (82%) and the superior orbital fissure (66%) was most often performed, and usually dural (47%) and bony defects (76%) were reconstructed. In almost all patients, visual acuity (91%; 95%CI 86\u201396%), visual fields (87%; 95%CI 70\u201399%) and proptosis (96%; 95%CI 90\u2013100%) improved. Furthermore, surgery showed improvement in 96% (95%CI 78\u2013100%) for both diplopia and ophthalmoplegia. The most common surgical complications were hypesthesia (19%; 95%CI 10\u201330%), ptosis and diplopia (both 17%; 95%CI, respectively, 10\u201326% and 5\u201333%) and ophthalmoplegia (16%; 95%CI 10\u201324).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with spheno\u2010orbital meningioma usually present with proptosis or unilateral decreased visual acuity. Surgery shows to be effective in improving visual acuity and visual field deficits with mostly minor and well\u2010tolerated complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14517","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T06:52:49Z","timestamp":1593499969000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Surgery as a safe and effective treatment option for spheno\u2010orbital meningioma: a systematic review and meta\u2010analysis of surgical techniques and outcomes"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-8342","authenticated-orcid":false,"given":"Fleur L.","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Leiden University Medical Center Leiden The 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