{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:57:58Z","timestamp":1767855478840,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report changes in the ocular surface and tear proteomics after discontinuation of chronic glaucoma medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients requiring trabeculectomy were recruited from the glaucoma clinic of Tampere University Hospital, Finland. Fifty\u2010seven patients with previous history of anti\u2010glaucomatous eye drops (8.1\u00a0\u00b1\u00a06.8\u00a0years) and having undergone a successful trabeculectomy were included in this report. Outcomes of interest were conjunctival redness grading, tear secretion (Schirmer I) and tear film proteomics (SWATH\u2010MS) in addition to thorough clinical examination. The protocol included five time points: preoperative visit and postoperative visits at month 1, 3, 6 and 12. All parameters measured were compared to the corresponding preoperative levels of each individual eye.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conjunctival redness and irritation were significantly reduced during follow\u2010up, while tear production remained unchanged. Protein profiles of the tear film indicated significant changes in the ocular surface. Lipid transport was increased while several pro\u2010inflammatory proteins were consistently decreased after the surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical signs as well as the proteomics results indicated that the trabeculectomy and resulting cessation of topical glaucoma medication were very beneficial to the ocular surface. The state of the conjunctiva improved throughout the 1\u2010year follow\u2010up while the levels of pro\u2010inflammatory proteins decreased and lipid transport\u2010associated functions were increased.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14526","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T07:23:11Z","timestamp":1594279391000},"page":"160-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of successful trabeculectomy on the ocular surface and tear proteomics\u2014a prospective cohort study with 1\u2010year follow\u2010up"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-2156","authenticated-orcid":false,"given":"Anu","family":"Vaajanen","sequence":"first","affiliation":[{"name":"Tays Eye Centre Tampere University Hospital Tampere 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