{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:06:15Z","timestamp":1775009175082,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Management of chronic vision threatening auto\u2010immune ocular diseases (AIOD, e.g. uveitis, scleritis) can be challenging. Guidelines recommend a multidisciplinary approach (MDA) with ophthalmologists and rheumatologists, to enhance the recognition of systemic diseases and guide the use of immunosuppressives. However, the indications and results of such an approach have not yet been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A monocentre, retrospective chart review of all patients treated in a MDA between ophthalmologists and rheumatologists, in a Dutch tertiary center. The collaboration was twofold: a combined multidisciplinary team meeting every 2\u00a0weeks, and an ophthalmology\u2010dedicated rheumatology outpatient clinic. Primary endpoints of this descriptive study were as follows: indications for MDA, new diagnoses of systemic auto\u2010immune diseases and changes in systemic immunosuppression and prednisone dosages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 157 adults (mean age 46\u00a0years, 57% female, median disease duration 19\u00a0months) were included, mainly with uveitis (74%) and scleritis (12%). Multidisciplinary approach (MDA)\u2010indications included diagnostic workup (32%), treatment support (44%), diagnostic\u2010and\u2010treatment support (10%) and side effects (8%). A systemic disease was newly diagnosed in eight and already present in 34 patients. At baseline, 54 patients used oral prednisone at &gt;7.5\u00a0mg\/day. Non\u2010corticoid immunosuppressives, mostly methotrexate, were started in 41% of the patients. During follow\u2010up, systemic prednisone was lowered to \u22647.5\u00a0mg\/day in 68% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This evaluation of an MDA\u2010programme in the management of AIOD demonstrated its added value. Mainly, it addressed the high demand for support in managing systemic immunosuppression, resulting in significant corticosteroid tapering. In addition, it resulted in the recognition of underlying systemic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14548","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:02:47Z","timestamp":1596553367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multidisciplinary management of auto\u2010immune ocular diseases in adult patients by ophthalmologists and rheumatologists"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-4235","authenticated-orcid":false,"given":"Rianne Elise","family":"Van Bentum","sequence":"first","affiliation":[{"name":"Departments of Rheumatology Amsterdam University Medical Center Location VU Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3270-6641","authenticated-orcid":false,"given":"Jesse M.","family":"Van den Berg","sequence":"additional","affiliation":[{"name":"Departments of Rheumatology Amsterdam University Medical Center Location VU Medical Center Amsterdam the Netherlands"},{"name":"Departments of Ophthalmology Amsterdam University Medical Center Location VU Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-2825","authenticated-orcid":false,"given":"Sanne E.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology Amsterdam University Medical Center Location VU Medical Center Amsterdam the Netherlands"},{"name":"Department of Ophthalmology Bergman Clinics Location Zaandam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-0151","authenticated-orcid":false,"given":"Joyce","family":"Van der Bijl","sequence":"additional","affiliation":[{"name":"Departments of Rheumatology Amsterdam University Medical Center Location VU Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-1048","authenticated-orcid":false,"given":"H. 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