{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:55:33Z","timestamp":1785192933307,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine microvascular changes in children with a history of retinopathy of prematurity (ROP) and in a control group of full\u2010term children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, 30 eyes of 15 children aged 6\u20138\u00a0years with a history of ROP were evaluated with swept\u2010source optical coherence tomography angiography (SS\u2010OCTA). Twenty\u2010eight eyes of 22 age\u2010matched full\u2010term children served as a healthy control group. The foveal avascular zone (FAZ), vessel density (VD) and choroidal vascular flow area (VFA) were evaluated on OCTA and correlated with central retinal thickness (CRT), visual acuity (VA), birth weight (BW), gestational age (GA) and ROP stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two eyes of 14 children with a history of ROP (stage 1\u20133) and 25 eyes of 19 full\u2010term children were available for evaluation. In the ROP group, the gestational age was 27\u00a0\u00b1\u00a02\u00a0weeks and birth weight was 781\u00a0\u00b1\u00a0164\u00a0g. In the ROP group, CRT was higher in the central ETDRS segment (mean difference [95% CI]: 32.8\u00a0\u00b5m [18.7; 47.0], p\u00a0=\u00a00.0002) compared to the controls. Smaller mean FAZ area (\u22120.12 [\u22120.19; \u22120.04], p\u00a0=\u00a00.004) and perimeter (\u2212662 [\u22121228; \u221296], p\u00a0=\u00a00.03) was found in comparison to the control group. An oval shape of the FAZ was observed among patients with a history of ROP. The mean central VD of the superficial plexus was 28\u00a0\u00b1\u00a08\/23\u00a0\u00b1\u00a08% and of the deep plexus 7\u00a0\u00b1\u00a07\/3\u00a0\u00b1\u00a05% (ROP group\/control group; p\u00a0&gt;\u00a00.05). No statistically significant difference was found regarding the choroidal VFA. Only weak correlation of FAZ and VD with function was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Swept\u2010source optical coherence tomography angiography imaging revealed significant microvascular anomalies in children with a history of ROP indicating disturbance of early morphological development of the central retina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14557","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:47:52Z","timestamp":1596556072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Retinal vessel architecture in retinopathy of prematurity and healthy controls using swept\u2010source optical coherence tomography angiography"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-7129","authenticated-orcid":false,"given":"Sandra","family":"Rezar\u2010Dreindl","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-9196","authenticated-orcid":false,"given":"Katharina","family":"Eibenberger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-7081","authenticated-orcid":false,"given":"Reinhard","family":"Told","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neumayer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Steiner","sequence":"additional","affiliation":[{"name":"Section for Medical Statistics Center for Medical Statistics, Informatics, and Intelligent Systems (CeMSIIS) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sacu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-7311","authenticated-orcid":false,"given":"Ursula","family":"Schmidt\u2010Erfurth","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Stifter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.02.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4162-y"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000866"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001471"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199603000-00017"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34247-6"},{"key":"e_1_2_5_8_1","first-page":"1217","article-title":"Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis","volume":"41","author":"Hughes S","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.004710"},{"key":"e_1_2_5_10_1","first-page":"e611","article-title":"Choroidal structural changes in preterm children with and without retinopathy of prematurity","volume":"98","author":"Lavric A","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.156"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14913"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.10.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8340729"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21417"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001937"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.01.011"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.12"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10599"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002616"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.4.507"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32833cd40b"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.001"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v5.i1.35"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22333"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000765"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0500-5"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38132"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.017"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.5052"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301612"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-017-0005-z"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.14557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T21:54:12Z","timestamp":1693691652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/aos.14557"],"URL":"https:\/\/doi.org\/10.1111\/aos.14557","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]},"assertion":[{"value":"2020-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}