{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:49:06Z","timestamp":1787996946852,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470613"],"award-info":[{"award-number":["81470613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670835"],"award-info":[{"award-number":["81670835"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700819"],"award-info":[{"award-number":["81700819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870642"],"award-info":[{"award-number":["81870642"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate changes in the tear film lipid layer thickness (LLT) in cataract patients with diabetes mellitus (DM) after cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited consecutive cataract patients and recorded data regarding DM condition. Lipid layer thickness (LLT) and partial blinks rates measured with the LipiView interferometer, tear break\u2010up time (TBUT) and Schirmer\u2019s tests, and dry eye symptoms evaluated with the Ocular Surface Disease Index (OSDI) questionnaire were conducted before and one month after cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, 38 age\u2010related cataract (ARC) and 31 diabetic cataract (DC) patients were available for analysis. No significant difference in preoperative LLT and partial blink rates was found between ARC and DC group. However, preoperative TBUT and Schirmer\u2019s test results were significantly lower in DC group compared to ARC group (both p\u00a0&lt;\u00a00.001). DC group showed higher preoperative OSDI score with no significant difference than ARC group (p\u00a0=\u00a00.279). In DC group, LLT was significantly thinner in cases with longer duration of DM (over 10\u00a0years) than in those with shorter duration (p\u00a0&lt;\u00a00.001). One month after surgery, LLT of DC group was significantly thinner than at baseline (pre: 65.7\u00a0\u00b1\u00a023.3, post: 51.3\u00a0\u00b1\u00a017.1, p\u00a0=\u00a00.002). While in ARC group, LLT had no significant difference before and after cataract surgery (pre: 67.1\u00a0\u00b1\u00a023.4, post: 60.2\u00a0\u00b1\u00a021.1, p\u00a0=\u00a00.078). Compared to baseline data, there was no statistically significant difference between two groups in the partial blink rates, TBUT and Schirmer\u2019s test results after cataract surgery (p<jats:italic>\u00a0<\/jats:italic>&gt;\u00a00.05). Ocular Surface Disease Index (OSDI) scores were significantly higher after surgery than at baseline in both ARC (pre: 8.9\u00a0\u00b1\u00a08.4, post: 12.4\u00a0\u00b1\u00a08.5, p\u00a0=\u00a00.003) and DC group (pre: 11.4\u00a0\u00b1\u00a010.3, post: 18.5\u00a0\u00b1\u00a08.5, p\u00a0=\u00a00.001). Multivariate linear regression analysis showed OSDI scores were associated with LLT either before or after cataract surgery (\u03b2\u00a0=\u00a0\u22120.862, p\u00a0&lt;\u00a00.001 and \u03b2\u00a0=\u00a0\u22120.592, p\u00a0&lt;\u00a00.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The tear film LLT is correlated with duration of DM and becomes significantly thinner one month after cataract surgery, leading to the aggravation of dry eye symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14565","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:42:27Z","timestamp":1596555747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Changes of the tear film lipid layer thickness after cataract surgery in patients with diabetes mellitus"],"prefix":"10.1111","volume":"99","author":[{"given":"Keke","family":"Zhang","sequence":"first","affiliation":[{"name":"Eye Institute, Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"NHC Key Laboratory of Myopia (Fudan University) Key Laboratory of Myopia Chinese Academy of Medical Sciences Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Institute, Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"NHC Key Laboratory of Myopia (Fudan University) Key Laboratory of Myopia Chinese Academy of Medical Sciences Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Beijing Children's Hospital National Center for Children's Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-8866","authenticated-orcid":false,"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Eye Institute, Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"NHC Key Laboratory of Myopia (Fudan University) Key Laboratory of Myopia Chinese Academy of Medical Sciences Shanghai 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