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However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full\u2010field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed full\u2010field electroretinography (RETI\u2010port\/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson\u2013Trick\u2013Litzkow fibre electrodes were used. Statistical analysis was performed and a p\u2010value &lt;0.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for multiple comparisons, both the light\u2010adapted 3.0 a\u2010wave implicit time (p\u00a0&lt;\u00a00.001) and 30\u2010Hertz flicker peak time (p\u00a0=\u00a00.012) showed significant difference between patients with late AMD and individuals without vitreoretinal disease. There was a significant difference in the light\u2010adapted 3.0 a\u2010wave implicit time (p\u00a0=\u00a00.011) between patients with early AMD and the control group, but the difference in 30\u00a0Hz flicker peak time was not significant (p\u00a0=\u00a00.256).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The difference in cone function measured by light\u2010adapted 3.0 a\u2010wave implicit time and 30\u2010Hertz flicker peak time in early and late AMD when compared to healthy controls suggests a more diminished overall response when AMD has reached later stages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14571","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T23:24:59Z","timestamp":1598311499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Full\u2010field electroretinography in age\u2010related macular degeneration: an overall retinal response"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-6514","authenticated-orcid":false,"given":"Thomas Richard Johansen","family":"Forshaw","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-6199","authenticated-orcid":false,"given":"Troels Wesenberg","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Neurophysiology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sten","family":"Andr\u00e9asson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-0199","authenticated-orcid":false,"given":"Torben Lykke","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1969.00990010209011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080230071024"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31817882db"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.09.039"},{"key":"e_1_2_5_6_1","first-page":"3278","article-title":"Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina","volume":"34","author":"Curcio CA","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_7_1","first-page":"1236","article-title":"Photoreceptor loss in age\u2010related macular degeneration","volume":"37","author":"Curcio CA","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12194"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.12.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1076\/opge.22.2.107.2226"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00367-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.04.014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.01-0787"},{"key":"e_1_2_5_14_1","first-page":"350","volume-title":"Sensory mechanisms of the retina: with an appendix on electroretinography","author":"Granit R","year":"1963"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/16.2.11"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.03.009"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.03.061"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e31817bff72"},{"key":"e_1_2_5_19_1","first-page":"41","volume-title":"2019\u20132020 basic and clinical science course. 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