{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:40:55Z","timestamp":1788230455525,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to evaluate parafoveal and peripapillary microvascular alterations in eyes with optic neuritis (ON) along with their fellow eyes compared to healthy control eyes using optical coherence tomography angiography (OCT\u2010A).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 31 ON\u2010affected eyes and 31 fellow eyes of 31 patients who had experienced unilateral ON and 33 eyes of 33 healthy controls in this exploratory retrospective cross\u2010sectional study. Optical coherence tomography angiography (OCT\u2010A) was used to generate microvascular structural images and quantify the vessel density of the superficial retinal capillary plexus (SRCP), the deep retinal capillary plexus (DRCP) and radial peripapillary capillary (RPC) segments. We used the Kruskal\u2013Wallis test for the comparison of OCT\u2010A results between the three groups and generalized estimating equation models for the pairwise comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences of SRCP (p\u00a0=\u00a00.0003) and RPC segment (p\u00a0&lt;\u00a00.0001) vessel densities between the three groups. Specifically, there was a reduction in parafoveal and peripapillary vessel density in the ON\u2010affected eyes compared to fellow eyes (SRCP, estimates, \u22121.97, 95% confidence interval [CI], \u22123.07, \u22120.87; RPC, \u22126.95, 95% CI, \u22128.70, \u22125.19) and controls (SRCP, \u22123.15, 95% CI, \u22124.61, \u22121.69; RPC, \u22128.66, 95% CI, \u221210.55, \u22126.76). The superior sector of the RPC segments vessel density in the fellow eyes was decreased compared to the controls (\u22124.93, 95% CI, \u22128.07, \u22121.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that microvascular changes occur in both the affected eye and unaffected fellow eye after a unilateral ON episode. Future studies are needed to clarify the clinical implications of these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14577","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T23:38:19Z","timestamp":1598312299000},"page":"288-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Peripapillary and parafoveal microvascular changes in eyes with optic neuritis and their fellow eyes measured by optical coherence tomography angiography: an Exploratory Study"],"prefix":"10.1111","volume":"99","author":[{"given":"Ga\u2010In","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-5635","authenticated-orcid":false,"given":"Kyung\u2010Ah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-6630","authenticated-orcid":false,"given":"Sei Yeul","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.08.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.10.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.03.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515590646"},{"key":"e_1_2_6_6_1","first-page":"329","article-title":"Mechanism of delayed conduction of fellow eyes in patients with optic neuritis","volume":"11","author":"Alshowaeir D","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3774-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000722"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00314-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"e0184927","DOI":"10.1371\/journal.pone.0184927","article-title":"Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases","volume":"12","author":"Chen TC","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222560110"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000775"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2020.1744164"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517750009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.040"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24351"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq080"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22554"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172168"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312231"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ca0135"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2018.0050"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509105228"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf087"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.04.026"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517729463"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2313030996"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.05.006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24194"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157645"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000655"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa3e"},{"key":"e_1_2_6_34_1","first-page":"767","article-title":"Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal\u2010appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis","volume":"28","author":"Saindane AM","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066271"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185115610935"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310477"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr264"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70259-X"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20575"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.12.036"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304547"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006873"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2014.984230"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2016.1259636"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:37:45Z","timestamp":1693327065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,24]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/aos.14577"],"URL":"https:\/\/doi.org\/10.1111\/aos.14577","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,24]]},"assertion":[{"value":"2019-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}