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A consecutive series of three pseudophakic patients (5 eyes) diagnosed with chronic aqueous misdirection after cataract surgery is presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A literature search identified 31 articles describing treatment of chronic aqueous misdirection with vitrectomy and a hyaloido\u2010zonula\u2010iridectomy. Studies, where patients were treated with a complete vitrectomy from pars plana in combination with a hyaloido\u2010zonula\u2010iridectomy, reported low relapse rates. Studies describing a surgical approach with vitrectomy performed from the anterior chamber, followed by a hyaloido\u2010zonula\u2010iridectomy, also reported low relapse rates except for one reporting relapse in nearly half of the patients. In our case series, a complete vitrectomy combined with a hyaloido\u2010zonula\u2010iridectomy resolved the chronic aqueous misdirection in all five eyes after one procedure except one eye where the hyaloido\u2010zonula\u2010iridectomy was repeated due to an insufficient opening. Some of the eyes still needed antiglaucomatous treatment due to chronic angle closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In treatment\u2010resistant malignant glaucoma, vitrectomy combined with a hyaloido\u2010zonula\u2010iridectomy should be considered performed to ensure communication between the anterior chamber and the vitreous cavity. If the condition has been unresolved for a long time, extensive synechiae of the angle may decrease the success rate due to chronic angle closure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14580","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T12:01:15Z","timestamp":1598356875000},"page":"251-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pars plana vitrectomy combined with hyaloido\u2010zonula\u2010iridectomy in treatment of patients with chronic aqueous misdirection: A systematic literature review and case series"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-6331","authenticated-orcid":false,"given":"Diana Chaban\u00e9","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Glostrup 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