{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:30:42Z","timestamp":1777955442707,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009123","name":"Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the changes over time and regional differences in the incidence of retinopathy of prematurity (ROP) in a national cohort of infants born &lt;28\u00a0weeks' gestational age (GA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based study of infants with GA &lt;28\u00a0weeks in Norway from 2009 to 2017. Prospectively collected data on clinical variables and outcomes were obtained from the Norwegian Neonatal Network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1499 live\u2010born infants transferred to a neonatal intensive care unit, 1156 were discharged alive. Four\u2010hundred and fifty\u2010eight infants (39.6%) had ROP, 152 (13.1%) had severe ROP, and 110 (9.5%) were treated for ROP. Eleven hundred infants (95.2%) had complete data sets. In a model comprising region of primary care, GA [odds ratios (OR): 0.65; 95% CI: 0.55\u20130.77], growth velocity (OR: 1.10; 95% CI: 1.00\u20132.00), medically treated patent ductus arteriosus (OR: 1.80; 95% CI: 1.19\u20132.72), weeks of supplemental oxygen (OR: 1.07; 95% CI: 1.03 to 1.11) and region of primary care (OR: 4.95; 95% CI: 3.05\u20138.04 for the pair of regions with the highest estimated OR) were significantly associated with severe ROP. Additionally, institutional differences for severe ROP were found, with ORs from 0.41 (95% CI: 0.05\u20133.23) to 5.36 (95% CI: 3.05\u20139.43) using the largest institution as reference. Incidences were stable over time after adjusting for GA. A larger proportion was treated with anti\u2010vascular endothelial growth factor after 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of severe ROP was stable between 2009 and 2017 in Norway. Regional and institutional differences need to be explored in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14593","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T16:26:28Z","timestamp":1600964788000},"page":"299-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Stable incidence but regional differences in retinopathy of prematurity in Norway from 2009 to 2017"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-1385","authenticated-orcid":false,"given":"Beanca Gj\u00f8lberg","family":"Grottenberg","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Internal Medicine Stavanger University Hospital Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katinka Madtzog","family":"Korseth","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Neurology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turid","family":"Follestad","sequence":"additional","affiliation":[{"name":"Department of Public Health and Nursing Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J\u00f8rgen","family":"Stensvold","sequence":"additional","affiliation":[{"name":"Norwegian Neonatal Network Oslo University Hospital Oslo Norway"},{"name":"Neonatal Department Division of Paediatric and Adolescent Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragnhild","family":"St\u00f8en","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Neonatology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-576X","authenticated-orcid":false,"given":"Dordi","family":"Austeng","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Ophthalmology St. Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"H628","article-title":"Increased thromboxane\u2010mediated contractions of retinal vessels of newborn pigs to peroxides","volume":"268","author":"Abran D","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013366"},{"key":"e_1_2_5_4_1","unstructured":"AustengD&LindqvistS(2017):Retningslinjer for screening av retinopathi hos premature; Nasjonal kvalitetsh\u00e5ndbok for den Norske \u00f8yelegeforening. 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