{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:45:47Z","timestamp":1790999147285,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate the long\u2010term efficacy and safety of two minimally invasive glaucoma surgery implants with a subconjunctival drainage approach: the XEN45 Gel Stent\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (Xen) implant and the PRESERFLO\u2122 MicroShunt (MicroShunt).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective comparative case series of primary open\u2010angle glaucoma (POAG) patients with at least 6\u00a0months of follow\u2010up after a MicroShunt or Xen implantation augmented with mitomycin C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one eyes of 31 patients underwent Xen implantation, and 41 eyes of 33 patients, MicroShunt implantation. Baseline characteristics were similar, except for more combined surgeries with phacoemulsification in the Xen group (37% vs. 2%). Mean baseline IOP\u00a0\u00b1\u00a0standard deviation dropped from 19.2\u00a0\u00b1\u00a04.4 to 13.8\u00a0\u00b1\u00a03.8\u00a0mmHg (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026) in the Xen group and from 20.1\u00a0\u00b1\u00a05.0 to 12.1\u00a0\u00b1\u00a03.5 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014) in the MicroShunt group at 24\u00a0months of follow\u2010up (p\u00a0=\u00a00.19, t\u2010test). The number of IOP\u2010lowering medications dropped from 2.5\u00a0\u00b1\u00a01.4 to 0.9\u00a0\u00b1\u00a01.2 in the Xen group and from 2.3\u00a0\u00b1\u00a01.5 to 0.7\u00a0\u00b1\u00a01.1 in the MicroShunt group. The probability of qualified success was 73% and 79% at 24\u00a0months of follow\u2010up for the Xen and MicroShunt groups, respectively. Postoperative complications were usually mild and self\u2010limiting. The number of bleb needling and secondary glaucoma surgery procedures was similar in both groups; however, in the Xen group more additional MicroPulse\n                      <jats:sup>\u00ae<\/jats:sup>\n                      transscleral cyclophotocoagulation procedures were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Xen Gel Stent and PreserFlo MicroShunt implantations achieved comparable results in POAG eyes in terms of IOP\u2010lowering and surgical success, with a similar high safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14602","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T03:20:16Z","timestamp":1601263216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["XEN\n                    <sup>\u00ae<\/sup>\n                    Gel Stent compared to PRESERFLO\u2122 MicroShunt implantation for primary open\u2010angle glaucoma: two\u2010year results"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-0540","authenticated-orcid":false,"given":"Lotte M.J.","family":"Scheres","sequence":"first","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefani","family":"Kujovic\u2010Aleksov","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-5281","authenticated-orcid":false,"given":"Wishal D.","family":"Ramdas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.P.C.","family":"de Crom","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne C.G.","family":"Roelofs","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-939X","authenticated-orcid":false,"given":"Tos T.J.M.","family":"Berendschot","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll A.B.","family":"Webers","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-1426","authenticated-orcid":false,"given":"Henny J.M.","family":"Beckers","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13601"},{"key":"e_1_2_5_3_1","first-page":"1945","article-title":"A review of the efficacy of mitomycin C in glaucoma filtration surgery","volume":"9","author":"Al Habash A","year":"2015","journal-title":"Clin Ophthalmol (Auckland 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