{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:50:06Z","timestamp":1792277406810,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the 3\u2010year treatment outcomes of XEN 45 gel stent in open\u2010angle glaucoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, single\u2010centre interventional study, consecutive eyes with uncontrolled intraocular pressure (IOP) or signs of disease progression despite medical treatment underwent XEN implantation either alone or combined with phacoemulsification (Phaco\u00a0+\u00a0XEN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Surgical success was defined as 'complete' when 36\u2010month unmedicated IOP was \u226415\u00a0mmHg with a relative IOP reduction\u00a0\u2265\u00a020% from medicated baseline, while the definition of qualified success allowed no more medications than at baseline. Other definitions of success with different IOP thresholds were also analysed. Secondary outcomes included mean IOP reduction, changes in ocular hypotensive medications and rates of reoperations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 149 eyes initially included, 92 eyes (61.7%) of 68 patients had complete 3\u2010year data (XEN: <jats:italic>n<\/jats:italic>\u00a0=\u00a026; Phaco\u00a0+\u00a0XEN: <jats:italic>n<\/jats:italic>\u00a0=\u00a066) after 38.2% were lost to follow\u2010up. Mean age was 76.3\u00a0\u00b1\u00a09.1\u00a0years, and 66.2% were female. Mean medicated IOP decreased from 20.8\u00a0\u00b1\u00a07.4\u00a0mmHg (21.0\u00a0\u00b1\u00a07.4 [XEN] vs. 20.0\u00a0\u00b1\u00a06.9\u00a0mmHg [Phaco\u00a0+\u00a0XEN]) at baseline to 13.1\u00a0\u00b1\u00a03.4\u00a0mmHg (12.9\u00a0\u00b1\u00a02.9 [XEN] vs. 12.9\u00a0\u00b1\u00a03.4 [Phaco\u00a0+\u00a0XEN]) at 3\u00a0years (\u221237.0%; p\u00a0&lt;\u00a00.001). Medications decreased from 1.9\u00a0\u00b1\u00a01.3 (2.4\u00a0\u00b1\u00a01.5 [XEN] vs. 1.9\u00a0\u00b1\u00a01.2 [Phaco\u00a0+\u00a0XEN]) to 0.4\u00a0\u00b1\u00a00.9 (0.3\u00a0\u00b1\u00a00.8 [XEN] vs. 0.5\u00a0\u00b1\u00a00.9 [Phaco\u00a0+\u00a0XEN]) (\u221278.9%; p\u00a0&lt;\u00a00.001). Complete success and qualified success were achieved in 29.0% and 31.0% of eyes, respectively. Needling revision was performed in 51 eyes (55.4%), and 26.1% underwent reoperations. Risk factors for surgical failure included male gender (odds ratio [OR]:3.6; p\u00a0=\u00a00.03), diagnosis of POAG (OR: 4.5; p\u00a0&lt;\u00a00.01) and undergoing needling revision (OR: 4.6; p\u00a0&lt;\u00a00.01). While the type of procedure had no effect on the outcomes of PEXG, POAG eyes undergoing combined surgery had significantly higher rates of failure (OR: 7.29; p\u00a0=\u00a00.023). Most patients stable at 12\u2010month remained so through to 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 3\u00a0years, XEN gel stent implantation achieved clinically significant IOP and medication reduction despite relatively high rates of needling and reoperations. Identifying patients at risk preoperatively may help optimize surgical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14605","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T13:51:55Z","timestamp":1624715515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Combined and stand\u2010alone XEN 45 gel stent implantation: 3\u2010year outcomes and success predictors"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-6253","authenticated-orcid":false,"given":"Kevin","family":"Gillmann","sequence":"first","affiliation":[{"name":"Glaucoma Research Center Montchoisi Clinic Swiss Visio Network Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-8715","authenticated-orcid":false,"given":"Giorgio 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