{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:15:58Z","timestamp":1780359358909,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the functional and anatomical outcomes of central retinal vein occlusion (CRVO) according to the presence of glaucoma before the onset of CRVO, and to assess whether pre\u2010existing glaucoma affects the prognosis of CRVO in terms of development and conversion to ischaemic CRVO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, patients with treatment\u2010na\u00efve CRVO were enrolled between December 2009 and February 2019. The patients were classified into two groups according to the presence of pre\u2010existing primary open\u2010angle glaucoma at CRVO diagnosis. We reviewed medical records regarding basic demographics, ocular characteristics and treatments. The effects of pre\u2010existing glaucoma on the occurrence of ischaemic CRVO were also investigated using Cox proportional hazard models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 166 eyes from 166 patients, 26 (15.7%) had pre\u2010existing glaucoma. The pre\u2010existing glaucoma group revealed significantly older (69.4\u00a0\u00b1\u00a013.3 versus 56.5\u00a0\u00b1\u00a015.9) and lower BCVA at baseline (1.06\u00a0\u00b1\u00a00.75 versus 0.64\u00a0\u00b1\u00a00.58, logMAR) and final visits (1.56\u00a0\u00b1\u00a01.35 versus 0.64\u00a0\u00b1\u00a00.48, logMAR) (all p\u00a0&lt;\u00a00.05) than non\u2010glaucomatous group. In terms of perfusion status of CRVO, the glaucoma group showed higher incidence of ischaemic CRVO (30.8% versus 5.3%, p\u00a0=\u00a00.052) at initial and last visits as well as more disorganization of retinal inner layers (DRIL) at 3\u00a0months (76.0% versus 49.6%, p\u00a0=\u00a00.015). Pre\u2010existing glaucoma (hazard ratio (HR)\u00a0=\u00a02.141, p\u00a0=\u00a00.014), lower vision at baseline (HR\u00a0=\u00a02.071, p\u00a0=\u00a00.001) and DRIL at 3\u00a0months (HR\u00a0=\u00a02.905, p\u00a0=\u00a00.011) were significant risk factors for the occurrence of ischaemic CRVO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with CRVO, pre\u2010existing glaucoma was associated with poorer visual and anatomical outcomes, and played as a significant risk factor for the development and conversion to ischaemic CRVO with lower vision and presence of DRIL at early phase of CRVO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14608","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:03:22Z","timestamp":1603919002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glaucoma as a prognostic factor of central retinal vein occlusion: visual and anatomical outcomes and occurrence of ischaemic central retinal vein occlusion"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-0738","authenticated-orcid":false,"given":"You Na","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Gone","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-7528","authenticated-orcid":false,"given":"Young Hee","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-9641","authenticated-orcid":false,"given":"Yoon Jeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Asan Medical Center 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