{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:33:36Z","timestamp":1777394016143,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","award":["Global Ophthalmology Fellowship Award"],"award-info":[{"award-number":["Global Ophthalmology Fellowship Award"]}],"id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report the use of flying baby spectral domain optical coherence tomography (SD\u2010OCT) on infants with advanced retinopathy of prematurity (ROP), where clinical findings alone failed to differentiate between retinoschisis and retinal detachment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, non\u2010interventional case\u2010series study of three premature infants with advanced ROP of clinically uncertain stage, after examination by indirect ophthalmoscopy. To confirm the diagnosis, table\u2010mounted SD\u2010OCT retinal imaging was performed with the infant held in the flying baby position under topical ocular anaesthesia only. Spectral domain optical coherence tomography (SD\u2010OCT) findings were correlated with clinical examination and ultra\u2010widefield scanning laser ophthalmoscopy to determine disease stage and appropriate management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The flying baby position was well tolerated, and SD\u2010OCT images of central and peripheral retina were successfully obtained in all three cases. Additional information provided by the SD\u2010OCT changed the ROP staging from 3 to 4 in one case, which subsequently required surgical treatment. In two other cases, clinical suspicion of stage 4 ROP was overruled as SD\u2010OCT revealed tractional retinoschisis rather than full\u2010thickness retinal detachment, thereby avoiding the need for immediate surgical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this case\u2010series study, flying baby SD\u2010OCT provided a rapid and widely accessible imaging approach that overruled clinical findings and altered classification and management of infants with advanced ROP. The methodology was suitable for outpatient settings with no risks associated with systemic anaesthesia. The increased use of OCT imaging will make apparent how structural information is useful in management of ROP and may influence future classification of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14613","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T05:54:21Z","timestamp":1604037261000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Flying baby optical coherence tomography alters the staging and management of advanced retinopathy of prematurity"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-6412","authenticated-orcid":false,"given":"Jasmina","family":"Cehajic\u2010Kapetanovic","sequence":"first","affiliation":[{"name":"Nuffield Laboratory of Ophthalmology University of Oxford Oxford UK"},{"name":"Oxford Eye Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanmin","family":"Xue","sequence":"additional","affiliation":[{"name":"Nuffield Laboratory of Ophthalmology University of Oxford Oxford UK"},{"name":"Oxford Eye Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Purohit","sequence":"additional","affiliation":[{"name":"Nuffield Laboratory of Ophthalmology University of Oxford Oxford UK"},{"name":"Oxford Eye Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.02.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.4796"},{"key":"e_1_2_7_5_1","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial","volume":"102","author":"Good WV","year":"2004","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02688.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208129"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450010031002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20070101-05"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.361"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20151027-08"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.10.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.45"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.02.020"},{"issue":"1","key":"e_1_2_7_17_1","first-page":"CD009734","article-title":"Anti\u2010vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity","volume":"1","author":"Sankar MJ","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v5.i1.35"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.12.025"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.313"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T16:51:49Z","timestamp":1693414309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/aos.14613"],"URL":"https:\/\/doi.org\/10.1111\/aos.14613","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"2020-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}